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  1. en.wikipedia.org › wiki › ParacetamolParacetamol - Wikipedia

    Paracetamol helps ductal closure in patent ductus arteriosus. It is as effective for this purpose as ibuprofen or indomethacin, but results in less frequent gastrointestinal bleeding than ibuprofen. [77] Its use for extremely low birth weight and gestational age infants however requires further study.

  2. Wikipedia is written by volunteer editors and hosted by the Wikimedia Foundation, a non-profit organization that also hosts a range of other volunteer projects : Commons. Free media repository. MediaWiki. Wiki software development.

  3. en.wikipedia.org › wiki › TramadolTramadol - Wikipedia

    Tramadol Hydrochloride (50mg) capsules made by Bristol Laboratories and provided by a pharmacy in England. Tramadol can have pharmacodynamic, pharmacokinetic, and pharmacogenetic interactions. Tramadol is metabolized by CYP2D6 enzymes which contribute to the metabolism of approximately 25% of all medications. [53]

  4. en.wikipedia.org › wiki › Citric_acidCitric acid - Wikipedia

    • Natural Occurrence and Industrial Production
    • Chemical Characteristics
    • Biochemistry
    • Applications
    • Synthesis of Other Organic Compounds
    • Safety
    • Compendial Status
    • See Also

    Citric acid occurs in a variety of fruits and vegetables, most notably citrus fruits. Lemons and limes have particularly high concentrations of the acid; it can constitute as much as 8% of the dry weight of these fruits (about 47 g/L in the juices).[a] The concentrations of citric acid in citrus fruits range from 0.005 mol/L for oranges and grapefr...

    Citric acid can be obtained as an anhydrous (water-free) form or as a monohydrate. The anhydrous form crystallizes from hot water, while the monohydrate forms when citric acid is crystallized from cold water. The monohydrate can be converted to the anhydrous form at about 78 °C. Citric acid also dissolves in absolute (anhydrous) ethanol (76 parts o...

    Citric acid cycle

    Citrate is an intermediate in the citric acid cycle, also known as the TCA (TriCarboxylic Acid) cycle or the Krebs cycle, a central metabolic pathway for animals, plants, and bacteria. Citrate synthase catalyzes the condensation of oxaloacetate with acetyl CoA to form citrate. Citrate then acts as the substrate for aconitase and is converted into aconitic acid. The cycle ends with regeneration of oxaloacetate. This series of chemical reactions is the source of two-thirds of the food-derived e...

    Other biological roles

    Citrate can be transported out of the mitochondria and into the cytoplasm, then broken down into acetyl-CoA for fatty acid synthesis, and into oxaloacetate. Citrate is a positive modulator of this conversion, and allosterically regulates the enzyme acetyl-CoA carboxylase, which is the regulating enzyme in the conversion of acetyl-CoA into malonyl-CoA(the commitment step in fatty acid synthesis). In short, citrate is transported into the cytoplasm, converted into acetyl-CoA, which is then conv...

    Food and drink

    Because it is one of the stronger edible acids, the dominant use of citric acid is as a flavoring and preservative in food and beverages, especially soft drinks and candies. Within the European Union it is denoted by E number E330. Citrate salts of various metals are used to deliver those minerals in a biologically available form in many dietary supplements. Citric acid has 247 kcal per 100 g. In the United States the purity requirements for citric acid as a food additive are defined by the F...

    Cleaning and chelating agent

    Citric acid is an excellent chelating agent, binding metals by making them soluble. It is used to remove and discourage the buildup of limescale from boilers and evaporators. It can be used to treat water, which makes it useful in improving the effectiveness of soaps and laundry detergents. By chelating the metals in hard water, it lets these cleaners produce foam and work better without need for water softening. Citric acid is the active ingredient in some bathroom and kitchen cleaning solut...

    Cosmetics, pharmaceuticals, dietary supplements, and foods

    Citric acid is used as an acidulantin creams, gels, and liquids. Used in foods and dietary supplements, it may be classified as a processing aid if it was added for a technical or functional effect (e.g. acidulent, chelator, viscosifier, etc.). If it is still present in insignificant amounts, and the technical or functional effect is no longer present, it may be exempt from labeling <21 CFR §101.100(c)>. Citric acid is an alpha hydroxy acidand is an active ingredient in chemical skin peels. C...

    Citric acid is a versatile precursor to many other organic compounds. Dehydration routes give itaconic acid and its anhydride. Citraconic acid can be produced via thermal isomerization of itaconic acid anhydride. The required itaconic acid anhydride is obtained by dry distillation of citric acid. Aconitic acid can be synthesized by dehydration of c...

    Although a weak acid, exposure to pure citric acid can cause adverse effects. Inhalation may cause cough, shortness of breath, or sore throat. Over-ingestion may cause abdominal pain and sore throat. Exposure of concentrated solutions to skin and eyes can cause redness and pain. Long-term or repeated consumption may cause erosion of tooth enamel.

    The closely related acids isocitric acid, aconitic acid, and propane-1,2,3-tricarboxylic acid(tricarballylic acid, carballylic acid)
  5. en.wikipedia.org › wiki › Dengue_feverDengue fever - Wikipedia

    Dengue fever is a mosquito-borne disease caused by dengue virus, prevalent in tropical and subtropical areas. It is frequently asymptomatic; if symptoms appear they typically begin 3 to 14 days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin itching and skin rash.

  6. en.wikipedia.org › wiki › CapybaraCapybara - Wikipedia

    Synonyms. Sus hydrochaeris Linnaeus, 1766. The capybara [a] or greater capybara ( Hydrochoerus hydrochaeris) is a giant cavy rodent native to South America. It is the largest living rodent [2] and a member of the genus Hydrochoerus. The only other extant member is the lesser capybara ( Hydrochoerus isthmius ).

  7. en.wikipedia.org › wiki › PiPi - Wikipedia

    The number π ( / paɪ /; spelled out as " pi ") is a mathematical constant that is the ratio of a circle 's circumference to its diameter, approximately equal to 3.14159. The number π appears in many formulae across mathematics and physics. It is an irrational number, meaning that it cannot be expressed exactly as a ratio of two integers, although fractions such as are commonly used to ...

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