Liquid chromatography-mass spectrometry wikipedia 相關
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Liquid chromatography–mass spectrometry ( LC–MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography – MS systems are popular in chemical analysis because the individual ...
Similarly to gas chromatography MS (GC-MS), liquid chromatography-mass spectrometry (LC/MS or LC-MS) separates compounds chromatographically before they are introduced to the ion source and mass spectrometer.
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What is liquid chromatography–mass spectrometry (LC–MS)?
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What is gas chromatography-mass spectrometry (GC-MS)?
Ion suppression in LC-MS and LC-MS/MS refers to reduced detector response, or signal:noise as a manifested effect of competition for ionisation efficiency in the ionisation source, between the analyte (s) of interest and other endogenous or exogenous (e.g. plasticisers extracted from plastic tubes, [1] mobile phase additives) species which have ...
Therefore, HPLC in this context is often performed in conjunction with mass spectrometry. Using liquid chromatography-mass spectrometry (LC-MS) instead of gas chromatography-mass spectrometry (GC-MS) circumvents the necessity for derivitizing with
Like liquid chromatography–mass spectrometry, it allows analysis and detection even of tiny amounts of a substance. [2] GC–MS has been regarded as a " gold standard " for forensic substance identification because it is used to perform a 100% specific test, which positively identifies the presence of a particular substance.
The most common use of this data representation is when mass spectrometry is used in conjunction with some form of chromatography, such as in liquid chromatography–mass spectrometry or gas chromatography–mass spectrometry. In this case, the x-axis represents retention time, analogous to any other chromatogram.
Gas chromatography-mass spectrometry (GC-MS) is a two-dimensional chromatography technique that combines the separation technique of gas chromatography with the identification technique of mass spectrometry. GC-MS is the single most important