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2024年5月22日 · What Is Tenormin? Tenormin (atenolol) is a beta-blocker indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions (heart attacks). What Are Side Effects of Tenormin? Side effects of Tenormin include:
- Mechanism of Action
- Pharmacodynamics
- Pharmacokinetics
- Specific Populations
- Drug Interaction Studies
- Glycemic Control Trials in Adults with Type 2 Diabetes Mellitus
- Heart Failure Trials in Adults
Empagliflozin is an inhibitor of SGLT2, the predominant transporter responsible for reabsorption of glucose from the glomerular filtrate back into the circulation. By inhibiting SGLT2, empagliflozin reduces renal reabsorption of filtered glucose and lowers the renal threshold for glucose, and thereby increases urinary glucose excretion. Empaglifloz...
In patients with type 2 diabetes mellitus, urinary glucose excretion increased immediately following a dose of empagliflozin and was maintained at the end of a 4-week treatment period averaging at approximately 64 grams per day with 10 mg empagliflozin and 78 grams per day with 25 mg empagliflozin once daily [see Clinical Studies]. Data from single...
The pharmacokinetics of empagliflozin has been characterized in healthy volunteers and patients with type 2 diabetes mellitus and no clinically relevant differences were noted between the two populations. The steadystate mean plasma AUC and Cmax were 1,870 nmol·h/L and 259 nmol/L, respectively, with 10 mg empagliflozin once daily treatment, and 4,...
The pharmacokinetics and pharmacodynamics of empagliflozin were investigated in pediatric patients aged 10 to 17 years with type 2 diabetes mellitus. Oral administration of empagliflozin at 10 mg and 25 mg resulted in exposure within the range observed in adult patients. Age, body mass index(BMI), gender and race (Asians versus primarily Whites) do...
Empagliflozin does not inhibit, inactivate, or induce CYP450 isoforms. In vitro data suggest that the primary route of metabolism of empagliflozin in humans is glucuronidation by the uridine 5'-diphosphoglucuronosyltransferases UGT1A3, UGT1A8, UGT1A9, and UGT2B7. Empagliflozin does not inhibit UGT1A1, UGT1A3, UGT1A8, UGT1A9, or UGT2B7. Therefore, n...
JARDIANCE has been studied as monotherapy and in combination with metformin, sulfonylurea, pioglitazone, linagliptin, and insulin. JARDIANCE has also been studied in patients with type 2 diabetes mellitus with mild or moderate renal impairment. In adult patients with type 2 diabetes mellitus, treatment with JARDIANCE reduced hemoglobin A1c(HbA1c), ...
EMPEROR-Reduced (NCT03057977) was a double-blind trial conducted in adults with chronic heart failure (New York Heart Association [NYHA] functional class II-IV) with left ventricular ejection fraction(LVEF) ≤40% to evaluate the efficacy of JARDIANCE as adjunct to standard of care heart failure therapy. Of 3,730 patients, 1,863 were randomized to JA...
2024年5月23日 · Wellbutrin (bupropion) is an antidepressant in the aminoketone class used for the management of major depression and seasonal affective disorder. Wellbutrin is available in generic form. What Are Side Effects of Wellbutrin? Wellbutrin may cause serious side effects including: seizure (convulsions), confusion, unusual changes in mood or behavior,
What Is Triglide? Triglide ( fenofibrate) helps reduce cholesterol and triglycerides ( fatty acids) in the blood and is used to treat high cholesterol and high triglyceride levels. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries). What Are Side Effects of Triglide?
2024年5月31日 · Prednisone is a prescription medication used most commonly to treat a variety of common diseases and conditions including acute asthma, rheumatic disorders, more. Learn about side effects, drug interactions, dosages, warnings, and more.
2024年5月31日 · Prednisone is a glucocorticoid indicated to treat or manage many conditions, including: endocrine disorders, rheumatic disorders, collagen diseases, dermatologic diseases, allergies, ophthalmic (eye) diseases, respiratory diseases, hematologic disorders, neoplastic diseases (cancers), edematous states, and. gastrointestinal diseases.
2024年5月17日 · Balversa (erdafitinib) is a kinase inhibitor indicated for the treatment of adult patients with locally advanced or metastatic urothelial carcinoma that has susceptible FGFR3 or FGFR2 genetic alterations, and progressed during or following at least one line of prior platinum-containing chemotherapy including within 12 months of neoadjuvant or ad...
