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  1. en.wikipedia.org › wiki › Unit_731Unit 731 - Wikipedia

    Unit 731 (Japanese: 731部隊, Hepburn: Nana-san-ichi Butai), short for Manchu Detachment 731 and also known as the Kamo Detachment: 198 and the Ishii Unit, was a covert biological and chemical warfare research and development unit of the Imperial Japanese Army that engaged in lethal human experimentation and biological weapons manufacturing during the Second Sino-Japanese War (1937–1945 ...

  2. en.wikipedia.org › wiki › BupropionBupropion - Wikipedia

    Bupropion, formerly called amfebutamone,[16] and sold under the brand name Wellbutrin among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation.[17][18] It is also popular as an add-on medication in the cases of "incomplete response" to the first-line selective serotonin ...

  3. en.wikipedia.org › wiki › Japanese_yenJapanese yen - Wikipedia

    Pronunciation and etymology The name, "Yen", derives from the Japanese word 圓 (en, ; "round"), which borrows its phonetic reading from Chinese yuan, similar to North Korean won and South Korean won.Originally, the Chinese had traded silver in mass called sycees, and when Spanish and Mexican silver coins arrived from the Philippines, the Chinese called them "silver rounds" (Chinese: 銀圓 ...

  4. 129,000–226,000. On 6 and 9 August 1945, the United States detonated two atomic bombs over the Japanese cities of Hiroshima and Nagasaki. The bombings killed between 129,000 and 226,000 people, most of whom were civilians, and remain the only use of nuclear weapons in an armed conflict. Japan surrendered to the Allies on 15 August, six days ...

    • Development of Thalidomide
    • Birth Defect Crisis
    • Aftermath of Scandal
    • Notable Cases
    • Change in Drug Regulations
    • External Links

    Thalidomide was first developed as a tranquilizer by Swiss pharmaceutical company Ciba in 1953.In 1954, Ciba abandoned the product, and it was acquired by German pharmaceutical company Chemie Grünenthal. The company had been established by Hermann Wirtz, Sr, a Nazi Party member, after World War II as a subsidiary of the family's Mäurer & Wirtz comp...

    The total number of embryos affected by the use of thalidomide during pregnancy is estimated at more than 10,000, and potentially up to 20,000; of these, approximately 40 percent died at or shortly after the time of birth. Those who survived had limb, eye, urinary tract, and heart defects. Its initial entry into the U.S. market was prevented by Fra...

    The numerous reports of malformations in babies brought about the awareness of the side effects of the drug on pregnant women. The birth defects caused by the drug thalidomide can range from moderate malformation to more severe forms. Possible birth defects include phocomelia, dysmelia, amelia, bone hypoplasticity, and other congenital defects affe...

    The disaster prompted many countries to introduce tougher rules for the testing and licensing of drugs, such as the Kefauver Harris Amendment (U.S.), Directive 65/65/EEC1 (E.U.), and the Medicines Act 1968 (UK). In the United States, the new regulations strengthened the FDA, among other ways, by requiring applicants to prove efficacy and to disclos...

  5. according to International Monetary Fund estimates [n 1] [1] Countries by nominal GDP in 2019 [n 2] > $20 trillion. $10–20 trillion. $5–10 trillion. $1–5 trillion. $750 billion – $1 trillion. $500–750 billion. $250–500 billion.

  6. Ludwigsburg Palace is a 452-room complex of 18 buildings in Ludwigsburg, Baden-Württemberg, Germany. It is the largest palatial estate in the country and has been called the " Versailles of Swabia ". Eberhard Louis, Duke of Württemberg, began construction of the palace in 1704. Charles Eugene, the son of his successor, completed it and ...

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