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Lin Dan (born 14 October 1983) [1] is a Chinese former professional badminton player. He is a two-time Olympic gold medallist, five-time World champion, two-time World Cup champion, as well as a six-time All England champion.
Michael Jeffrey Jordan (born February 17, 1963), also known by his initials MJ,[9] is an American businessman and former professional basketball player. He played fifteen seasons in the National Basketball Association (NBA) between 1984 and 2003, winning six NBA championships with the Chicago Bulls. He was integral in popularizing basketball ...
- Contraindications
- Interactions
- Pharmacology
- Chemistry
- History
- Society and Culture
Oral dantrolene is contraindicated for 1. patients with active hepatic disease 2. patients in whom spasticity is utilized to maintain upright posture and balance 3. patients with a hypersensitivity to dantrolene There are no contraindications for intravenous dantrolene used for prophylaxis or management of malignant hyperthermia.
Dantrolene may interact with the following drugs: 1. Calcium channel blockers of the diltiazem/verapamil type: Intravenous treatment with dantrolene and concomitant calcium channel blocker treatment may lead to severe cardiovascular collapse, abnormal heart rhythms, myocardial depressions, and high blood potassium. 2. Nondepolarizing neuromuscular ...
Dantrolene depresses excitation-contraction coupling in skeletal muscle by acting as a receptor antagonist to the ryanodine receptor, and decreasing free intracellular calciumconcentration.
Chemically it is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. The poor water solubility of dantrolene leads to certain difficulties in its use. A more water-soluble analog of dantrolene, azumolene, is under development for similar indications. Azumolene has a bromine residue i...
Dantrolene was first described in the scientific literature in 1967, as one of several hydantoin derivatives proposed as a new class of muscle relaxant. Dantrolene underwent extensive further development, and its action on skeletal musclewas described in detail in 1973. Dantrolene was widely used in the management of spasticity before its efficacy ...
Legal status
In March 2024, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Agilus, intended for the treatment of malignant hyperthermia in combination with adequate support measures. The applicant for this medicinal product is Norgine B.V. In the formulation of Agilus, the mannitol and sodium hydroxide have been replaced with hydroxypropyl-beta-cycl...
Worldwide. Part of Solar cycle 10. The Carrington Event was the most intense geomagnetic storm in recorded history, peaking on 1–2 September 1859 during solar cycle 10. It created strong auroral displays that were reported globally and caused sparking and even fires [citation needed] in telegraph stations. [1]
Early life Awkwafina was born in Stony Brook, New York, to Wally Lum, a Chinese American, and Tia Lum, a Korean American. Her father worked in the information technology field, and comes from a family of restaurateurs—her great-grandfather immigrated to the United States in the 1940s, and opened the Cantonese restaurant Lum's in Flushing, Queens, one of the neighborhood's first Chinese ...
Laufey. Laufey Lín Bing Jónsdóttir ( Icelandic: [ˈlœyːvei ˈliːn ˈjounsˌtouhtɪr̥]; Chinese: 林冰; pinyin: Lín Bīng; born 23 April 1999), known mononymously as Laufey ( / ˈleɪveɪ / LAY-vay ), is an Icelandic singer-songwriter and record producer. She achieved prominence in the early 2020s for her success as a jazz-inspired pop ...
Zhangye National Geopark (simplified Chinese: 张掖国家地质公园; traditional Chinese: 張掖國家地質公園; pinyin: Zhāngyè Guójiā Dìzhìgōngyuán) is located in Sunan and Linze counties within the prefecture-level city of Zhangye, in Gansu, China. It covers an area of 322 square kilometres (124 sq mi). The site became a quasi ...
