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Oxycodone, sold under various brand names such as Roxicodone and OxyContin (which is the extended release form), is a semi-synthetic opioid used medically for treatment of moderate to severe pain. It is highly addictive[14] and is a commonly abused drug.[15][16] It is usually taken by mouth, and is available in immediate-release and controlled ...
Unit 731 (Japanese: 731部隊, Hepburn: Nana-san-ichi Butai), short for Manchu Detachment 731 and also known as the Kamo Detachment: 198 and the Ishii Unit, was a covert biological and chemical warfare research and development unit of the Imperial Japanese Army that engaged in lethal human experimentation and biological weapons manufacturing during the Second Sino-Japanese War (1937–1945 ...
The Boundary Fire was a 2017 wildfire in Arizona that burned 17,788 acres (7,199 ha) of the Coconino and Kaibab National Forests. The fire was ignited on June 1 when lightning struck a spot on the northeast side of Kendrick Peak within the Coconino National Forest. The fire spread rapidly because of high temperatures, steep terrain, leftovers ...
- Development of Thalidomide
- Birth Defect Crisis
- Aftermath of Scandal
- Notable Cases
- Change in Drug Regulations
- External Links
Thalidomide was first developed as a tranquilizer by Swiss pharmaceutical company Ciba in 1953.In 1954, Ciba abandoned the product, and it was acquired by German pharmaceutical company Chemie Grünenthal. The company had been established by Hermann Wirtz, Sr, a Nazi Party member, after World War II as a subsidiary of the family's Mäurer & Wirtz comp...
The total number of embryos affected by the use of thalidomide during pregnancy is estimated at more than 10,000, and potentially up to 20,000; of these, approximately 40 percent died at or shortly after the time of birth. Those who survived had limb, eye, urinary tract, and heart defects. Its initial entry into the U.S. market was prevented by Fra...
The numerous reports of malformations in babies brought about the awareness of the side effects of the drug on pregnant women. The birth defects caused by the drug thalidomide can range from moderate malformation to more severe forms. Possible birth defects include phocomelia, dysmelia, amelia, bone hypoplasticity, and other congenital defects affe...
Niko von Glasow, a thalidomide survivor, produced a documentary called NoBody's Perfect, based on the lives of 12 people affected by the drug, which was released in 2008.The disaster prompted many countries to introduce tougher rules for the testing and licensing of drugs, such as the Kefauver Harris Amendment (U.S.), Directive 65/65/EEC1 (E.U.), and the Medicines Act 1968 (UK). In the United States, the new regulations strengthened the FDA, among other ways, by requiring applicants to prove efficacy and to disclos...
Exhuma. Exhuma ( Korean : 파묘) is a 2024 South Korean supernatural horror film written and directed by Jang Jae-hyun, and starring Choi Min-sik, Kim Go-eun, Yoo Hae-jin and Lee Do-hyun. The film includes mystery and occult elements, and follows the process of excavating an ominous grave, which unleashes dreadful consequences buried underneath.
Methamphetamine [note 1] (contracted from N- methylamphetamine) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. [22] Methamphetamine was discovered in 1893 and exists as two enantiomers: levo ...
Paul Joseph Goebbels ( German: [ˈpaʊ̯l ˈjoːzɛf ˈɡœbl̩s] ⓘ; 29 October 1897 – 1 May 1945) was a German Nazi politician and philologist who was the Gauleiter (district leader) of Berlin, chief propagandist for the Nazi Party, and then Reich Minister of Propaganda from 1933 to 1945. He was one of Adolf Hitler 's closest and most ...
