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Vitamin C (also known as ascorbic acid and ascorbate) is a water-soluble vitamin found in citrus and other fruits, berries and vegetables. It is also a generic prescription medication and in some countries is sold as a non-prescription dietary supplement. As a therapy, it is used to prevent and treat scurvy, a disease caused by vitamin C ...
Taiwan,[II][k] officially the Republic of China (ROC),[I][l] is a country[27] in East Asia.[o] It is located at the junction of the East and South China Seas in the northwestern Pacific Ocean, with the People's Republic of China (PRC) to the northwest, Japan to the northeast, and the Philippines to the south. The territories controlled by the ...
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- Natural Occurrence and Industrial Production
- Chemical Characteristics
- Biochemistry
- Applications
- Synthesis of Other Organic Compounds
- Safety
- Compendial Status
- See Also
Citric acid occurs in a variety of fruits and vegetables, most notably citrus fruits. Lemons and limes have particularly high concentrations of the acid; it can constitute as much as 8% of the dry weight of these fruits (about 47 g/L in the juices).[a] The concentrations of citric acid in citrus fruits range from 0.005 mol/L for oranges and grapefr...
Citric acid can be obtained as an anhydrous (water-free) form or as a monohydrate. The anhydrous form crystallizes from hot water, while the monohydrate forms when citric acid is crystallized from cold water. The monohydrate can be converted to the anhydrous form at about 78 °C. Citric acid also dissolves in absolute (anhydrous) ethanol (76 parts o...
Citric acid cycle
Citrate is an intermediate in the citric acid cycle, also known as the TCA (TriCarboxylic Acid) cycle or the Krebs cycle, a central metabolic pathway for animals, plants, and bacteria. Citrate synthase catalyzes the condensation of oxaloacetate with acetyl CoA to form citrate. Citrate then acts as the substrate for aconitase and is converted into aconitic acid. The cycle ends with regeneration of oxaloacetate. This series of chemical reactions is the source of two-thirds of the food-derived e...
Other biological roles
Citrate can be transported out of the mitochondria and into the cytoplasm, then broken down into acetyl-CoA for fatty acid synthesis, and into oxaloacetate. Citrate is a positive modulator of this conversion, and allosterically regulates the enzyme acetyl-CoA carboxylase, which is the regulating enzyme in the conversion of acetyl-CoA into malonyl-CoA(the commitment step in fatty acid synthesis). In short, citrate is transported into the cytoplasm, converted into acetyl-CoA, which is then conv...
Food and drink
Because it is one of the stronger edible acids, the dominant use of citric acid is as a flavoring and preservative in food and beverages, especially soft drinks and candies. Within the European Union it is denoted by E number E330. Citrate salts of various metals are used to deliver those minerals in a biologically available form in many dietary supplements. Citric acid has 247 kcal per 100 g. In the United States the purity requirements for citric acid as a food additive are defined by the F...
Cleaning and chelating agent
Citric acid is an excellent chelating agent, binding metals by making them soluble. It is used to remove and discourage the buildup of limescale from boilers and evaporators. It can be used to treat water, which makes it useful in improving the effectiveness of soaps and laundry detergents. By chelating the metals in hard water, it lets these cleaners produce foam and work better without need for water softening. Citric acid is the active ingredient in some bathroom and kitchen cleaning solut...
Cosmetics, pharmaceuticals, dietary supplements, and foods
Citric acid is used as an acidulantin creams, gels, and liquids. Used in foods and dietary supplements, it may be classified as a processing aid if it was added for a technical or functional effect (e.g. acidulent, chelator, viscosifier, etc.). If it is still present in insignificant amounts, and the technical or functional effect is no longer present, it may be exempt from labeling <21 CFR §101.100(c)>. Citric acid is an alpha hydroxy acidand is an active ingredient in chemical skin peels. C...
Citric acid is a versatile precursor to many other organic compounds. Dehydration routes give itaconic acid and its anhydride. Citraconic acid can be produced via thermal isomerization of itaconic acid anhydride. The required itaconic acid anhydride is obtained by dry distillation of citric acid. Aconitic acid can be synthesized by dehydration of c...
Although a weak acid, exposure to pure citric acid can cause adverse effects. Inhalation may cause cough, shortness of breath, or sore throat. Over-ingestion may cause abdominal pain and sore throat. Exposure of concentrated solutions to skin and eyes can cause redness and pain. Long-term or repeated consumption may cause erosion of tooth enamel.
The closely related acids isocitric acid, aconitic acid, and propane-1,2,3-tricarboxylic acid(tricarballylic acid, carballylic acid)Claude Debussy. Debussy c. 1900 by Atelier Nadar. ( Achille) Claude Debussy [n 1] ( French: [aʃil klod dəbysi]; 22 August 1862 – 25 March 1918) was a French composer. He is sometimes seen as the first Impressionist composer, although he vigorously rejected the term. He was among the most influential composers of the late 19th and early 20th ...
Charles Robert Darwin FRS FRGS FLS FZS JP [6] ( / ˈdɑːrwɪn / [7] DAR-win; 12 February 1809 – 19 April 1882) was an English naturalist, geologist and biologist, [8] widely known for his contributions to evolutionary biology. His proposition that all species of life have descended from a common ancestor is now generally accepted and ...
The wolf ( Canis lupus; [b] pl.: wolves ), also known as the gray wolf or grey wolf, is a large canine native to Eurasia and North America. More than thirty subspecies of Canis lupus have been recognized, including the dog and dingo, though gray wolves, as popularly understood, only comprise naturally-occurring wild subspecies.
Charles Dickens's birthplace, 393 Commercial Road, Portsmouth 2 Ordnance Terrace, Chatham, Dickens's home 1817 – May 1821 Charles Dickens was born on 7 February 1812 at 1 Mile End Terrace (now 393 Commercial Road), Landport in Portsea Island (), Hampshire, the second of eight children of Elizabeth Dickens (née Barrow; 1789–1863) and John Dickens (1785–1851).
