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Cristiano Ronaldo is the most-followed individual, sportsperson, footballer, Portuguese and European on Instagram. Lionel Messi is the most-followed Argentinian and South American on Instagram. Selena Gomez is the most-followed woman, actress, musician, American and North American on Instagram. Virat Kohli is the most-followed Indian, cricketer ...
Instagram[a] is a photo and video sharing social networking service owned by Meta Platforms. It allows users to upload media that can be edited with filters, be organized by hashtags, and be associated with a location via geographical tagging. Posts can be shared publicly or with preapproved followers. Users can browse other users' content by ...
The Tortured Poets Department. The Tortured Poets Department [a] is the eleventh studio album by the American singer-songwriter Taylor Swift, released on April 19, 2024, through Republic Records. It was expanded into a double album two hours after its release, subtitled The Anthology, containing a second volume of songs.
- Signs and Symptoms
- Cause
- Pathophysiology
- Diagnosis
- Treatment
- Prognosis
- Epidemiology
85–90% of IgA-deficient individuals are asymptomatic, although the reason for lack of symptoms is relatively unknown and continues to be a topic of interest and controversy. Some patients with IgA deficiency have a tendency to develop recurrent sinopulmonary infections, gastrointestinal infections and disorders, allergies, autoimmune conditions, an...
Selective IgA deficiency is inherited in less than half of cases, but has been associated with differences in chromosomes 18, 14 and 6. Selective IgA deficiency is often inherited, but fewer than half of all cases but has been associated with some congenital intrauterine infections.
Pathogenesis of IgA Deficiency ‘In IgA-deficient patients, the common finding is a maturation defect in B cells to produce IgA’. ‘In IgA deficiency, B cells express IgA; however, they are of immature phenotypewith the coexpression of IgM and IgD, and they cannot fully develop into IgA-secreting plasma cells’. There is an inherited inability to prod...
When suspected, the diagnosis can be confirmed by laboratory measurement of IgA level in the blood. SIgAD is an IgA level < 7 mg/dL with normal IgG and IgM levels (reference range 70–400 mg/dL for adults; children somewhat less).
The treatment consists of identification of co-morbid conditions, preventive measures to reduce the risk of infection, and prompt and effective treatment of infections. Infections in an IgA-deficient person are treated as usual (i.e., with antibiotics). There is no treatment for the underlying disorder.All SIgAD patients, even if asymptomatic, shou...
Prognosis is excellent, although there is an association with autoimmune disease. Of note, selective IgA deficiency can complicate the diagnosis of one such condition, celiac disease, as the deficiency masks the high levels of certain IgA antibodiesusually seen in celiac disease. As opposed to the related condition CVID, selective IgA deficiency is...
Prevalence varies by population, but is on the order of 1 in 100 to 1 in 1000 people, making it relatively common. SIgAD occurs in 1 in 39 to 1 in 57 people with celiac disease. This is much higher than the prevalence of selective IgA deficiency in the general population. It is also significantly more common in those with type 1 diabetes.[citation ...
Nicholas of Worcester (died 1124) was the prior of the Benedictine priory of Worcester Cathedral (crypt pictured) from about 1115 until his death. He was born around the time of the Norman Conquest.It is not known who his parents were, but William of Malmesbury wrote that he was "of exalted descent", and it has been argued that he was a son of King Harold Godwinson.
Shou Zi Chew. Shou Zi Chew ( Chinese: 周受资; born 1 January 1983) is a Singaporean businessman who has been serving as the chief executive officer of TikTok, an online video platform owned by Chinese company ByteDance, since 2021.
Albert Einstein ( / ˈaɪnstaɪn / EYEN-styne; [4] German: [ˈalbɛɐt ˈʔaɪnʃtaɪn] ⓘ; 14 March 1879 – 18 April 1955) was a German-born theoretical physicist who is widely held to be one of the greatest and most influential scientists of all time. Best known for developing the theory of relativity, Einstein also made important ...
