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- 19.59-0.08 (-0.41%)2024/08/22 22:27 臺灣股市 已收盤 (報價延遲20分鐘)。
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编辑. 1949年12月，兼沅陵军分区，1950年8月，免兼军分区，组建会同军分区机关。. 1952年8月，改会同军分区为芷江军分区。. 1953年1月，芷江军分区又改称为黔阳军分区。. 1981年8月，黔阳军分区改称怀化军分区。. [1]
- 概览
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复旦大学教授、博士生导师
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沈侠，男，博士，复旦大学生命科学学院、遗传工程国家重点实验室、国际人类表型组研究院、粤港澳大湾区精准医学研究院（广州）研究员 、博士生导师，爱丁堡大学（University of Edinburgh）名誉研究员 。
Biostatistics: Statistical Genetics, Quantitative Genetics, Genetics of Complex Traits, Bioinformatics
2007年本科毕业于中国人民大学统计学院，2012年于瑞典乌普萨拉大学（Uppsala University）获得生物信息学博士学位；致力于统计遗传学方法的创新研究与多组学大数据整合分析，研究领域涉及数理科学、计算科学、生命科学等多学科交叉融合；归国前曾任英国爱丁堡大学（University of Edinburgh）与瑞典卡罗琳斯卡医学院（Karolinska Institutet）两所国际知名院校生物统计学与统计遗传学助理教授、博士生导师；2018年至2021年曾任中山大学生命科学学院教授、博士生导师。在国际学术期刊共发表论文50余篇，其中代表性研究成果发表于Nature Genetics、Nature Communications、Circulation、American Journa...
教材
•Shen H, Yan Q, Shen X (沈恒范, 严钦容, 沈侠) (2017): Probability and Mathematical Statistics (6th Edition Textbook) (概率论与数理统计教程 第六版, “十二五”普通高等教育本科国家级规划教材). Higher Education Press (高等教育出版社). ISBN 978-7-04-048049-8.
论文
•Yang Z, Macdonald-Dunlop E, Chen J, Zhai R, Li T, Richmond A, Klaric L, Pirastu N,Ning Z, Zheng C, Wang Y, Huang T, He Y, Guo H, Ying K, Gustafsson S, Prins B,Ramisch A, Dermitzakis ET, Png G, Eriksson N, Haessler J, Hu X, Zanetti D,Boutin T, Hwang S-J, Wheeler E, Pietzner M, Raffield LM, Kalnapenkis A, PetersJE, Viñuela A, Gilly A, Elmståhl S, Dedoussis G, Petrie JR, Polašek O,Folkersen L, Chen Y, Yao C, Võsa U, Pairo-Castineira E, Clohisey S, BretherickAD, Rawlik K, GenOMICC Consortium, IMI-DIRECT Consortium, Esko T, Enroth S,Johansson Å, Gyllensten U, Langenberg C, Levy D, Hayward C, Assimes TL,Kooperberg C, Manichaikul AW, Siegbahn A, Wallentin L, Lind L, Zeggini E,Schwenk JM, Butterworth AS, Michaëlsson K, Pawitan Y, Joshi PK, Baillie JK, MälarstigA, Reiner AP, Wilson JF, Shen X (2022). Genetic landscape of the ACE2 coronavirus receptor. Circulation, 145: 1398–1411. •Zhai R, Pan L, Yang Z, Li T, Ning Z, Pawitan Y, Wilson JF, Wu D, Shen X (2022). Genetic and phenotypic links between obesity and extracellular vesicles. Human Molecular Genetics, ddac069. •Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott ES, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar A, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, KosmickiJA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD, Verma A, Fowle TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A, GenOMICC Investigators, 23andMe, Covid-19 Human GeneticsInitiative, Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK (2022). Whole genome sequencing reveals host factors underlying critical Covid-19. Nature. •Yang Z, Xu W, Zhai R, Li T, Ning Z, Pawitan Y, Shen X (2022). Integration of distinct analysis strategies improves tissue-trait association identification. Frontiers in Genetics, 12: 787107. •Png G, Barysenka A, Repetto L, Navarro P, Shen X, Pietzner M, Wheeler E, Wareham N, Langenberg C, TsafantakisE, Karaleftheri M, Dedoussis G, Mälarstig A, Wilson JF, Gilly A, Zeggini E(2021). Mapping the serum proteome to neurological diseases using whole genome sequencing. Nature Communications,12, 7042. •Ying K, Zhai R, Pyrkov TV, Shindyapina AV, Mariotti M, Fedichev PO, Shen X, Gladyshev VN (2021).Genetic and phenotypic analysis of the causal relationship between aging andCOVID-19. Communications Medicine,1:35. •He Y, Shu C, Li T, Wu Q, Wang Z, Chen X, Shen X (2021). Non-inferiority in cancer clinical trials was associated with more lenient margins and higher hypothesized outcome event rates. Journal of Clinical Epidemiology,139, 214-221. •Li T, Ning Z, Shen X (2021). Improved estimation of phenotypic correlations using summary association statistics. Frontiers in Genetics, 12: 665252. •Li T, Ning Z, Yang Z, Zhai R, Xu W, Ying K, Wang Y, Chen Y, Shen X (2021). Total genetic contribution assessment across the human genome. Nature Communications, 12, 1845. •Ning Z, Tsepilov YA, Sharapov SZ, Wang Z, Grishenko AK, Feng X, Shirali M, Joshi PK, Wilson JF, Pawitan Y, Haley CS, Aulchenko YS, Shen X (2021). Nontrivial Replication of Loci Detectedby Multi-Trait Methods. Frontiers in Genetics, 12: 627989. •Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, ParkinsonN, Fourman MH, Russell CD, Furniss J, Richmond A, Gountouna E, Wrobel N, Harrison D, Wang B, Wu Y, Meynert A, Griffiths F, Oosthuyzen W, Kousathanas A, Moutsianas L, Yang Z, Zhai R, Zheng C, Grimes G, Beale R, Millar J, Shih B, KeatingS, Zechner M, Haley C, Porteous DJ, Hayward C, Yang J, Knight J, Summers C, Shankar-Hari M, Klenerman P, Turtle L, Ho A, Moore SC, Hinds C, Horby P, NicholA, Maslove D, Ling L, McAuley D, Montgomery H, Walsh T, Pereira A, Renieri A; GenOMICC Investigators; ISARICC Investigators; COVID-19 Human GeneticsInitiative; 23andMe Investigators; BRACOVID Investigators; Gen-COVIDInvestigators, Shen X, Ponting CP, Fawkes A, Tenesa A, Caulfield M, Scott R, Rowan K, Murphy L, Openshaw PJM, Semple MG, Law A, Vitart V, Wilson JF, Baillie JK (2021). Genetic mechanisms of critical illness in Covid-19. Nature, 591: 92-98. •Ning Z, Pawitan Y, Shen X (2020).High-definition likelihood inference of genetic correlations across human complex traits. Nature Genetics,52: 859–864. •Wu D, Yan J, Shen X, Sun Y, Thulin M, Cai Y, Wik L, Shen Q, Oelrich J, Qian X, Dubois KL, Ronquist KG,Nilsson M, Landegren U, Kamali-Moghaddam M (2019). Profiling surface proteins on individual exosomes using a proximity barcoding assay. Nature Communications, 10, 3854; doi:10.1038/s41467-017-00934-5. •Li T, Shen X (2019). Pleiotropy complicates human gene editing: CCR5Δ32 and beyond. Frontiers in Genetics, 10: 669. •Timmers PRHJ, Mounier N, Läll K, Fischer K, Ning Z, Feng X, Bretherick A, Clark DW, eQTLGen Consortium, Shen X, Esko T, Kutalik Z, Wilson JF, Joshi PK (2019): Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances. eLife,8:e39856. •Ning Z, Lee Y, Joshi PK, Wilson JF, Pawitan Y, Shen X (2017): A selection operator for summary association statistics reveals allelic heterogeneity of complex traits. American Journal of Human Genetics,101(6): 903-912. •Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E, Schraut KE, Clark DW, NutileT, Barnes CLK, Timmers PRHJ, Shen X,Gandin I, McDaid AF, Hansen TF, Gordon SD, Giulianini F, Boutin TS, AbdellaouiA, Zhao W, Medina-Gomez C, Bartz TM, Trompet S, Lange LA, Raffield L, van derSpek A, Galesloot TE, Proitsi P, Yanek LR, Bielak LF, Payton A, Murgia F,Concas MP, Biino G, Tajuddin SM, Seppälä I, Amin N, Boerwinkle E, Børglum AD,Campbell A, Demerath EW, Demuth I, Faul JD, Ford I, Gialluisi A, Gögele M,Graff M, Hingorani A, Hottenga JJ, Hougaard DM, Hurme MA, Ikram MA, Jylhä M,Kuh D, Ligthart L, Lill CM, Lindenberger U, Lumley T, Mägi R, Marques-Vidal P,Medland SE, Milani L, Nagy R, Ollier WER, Peyser PA, Pramstaller PP, Ridker PM,Rivadeneira F, Ruggiero D, Saba Y, Schmidt R, Schmidt H, Slagboom PE, Smith BH,Smith JA, Sotoodehnia N, Steinhagen-Thiessen E, van Rooij FJA, Verbeek AL,Vermeulen SH, Vollenweider P, Wang Y, Werge T, Whitfield JB, Zonderman AB,Lehtimäki T, Evans MK, Pirastu M, Fuchsberger C, Bertram L, Pendleton N, KardiaSLR, Ciullo M, Becker DM, Wong A, Psaty BM, van Duijn CM, Wilson JG, Jukema JW,Kiemeney L, Uitterlinden AG, Franceschini N, North KE, Weir DR, Metspalu A,Boomsma DI, Hayward C, Chasman D, Martin NG, Sattar N, Campbell H, Esko T,Kutalik Z, Wilson JF (2017): Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with humanlongevity. Nature Communications,8, 910; doi: 10.1038/s41467-017-00934-5. •Shen X, Klarić L, Sharapov S, Mangino M, Ning Z, Wu D, Trbojević-Akmačić I, Pučić-Baković M, Rudan I, Polašek O, Hayward C, Spector TD, Wilson JF, Lauc G, Aulchenko YS (2017): Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation. Nature Communications, 8, 447. •Wang B, Li Z, Xu W, Feng X, Wan Q, Zan Y, Sheng S, Shen X (2017): Bivariate genomic analysis identifies a hidden locus associated with bacteria hypersensitive response in Arabidopsisthaliana. Scientific Reports,7, 45281. •Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI,Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A; BIOS Consortium,Ahluwalia TS, Albrecht E, Yerges-Armstrong L, Atzmon G, Auro K, Ayers K, BakshiA, Ben-Avraham D, Berger K, Bergman A, Bertram L, Bielak LF, Bjornsdottir G,Bonder MJ, Broer L, Bui M, Barbieri C, Cavadino A, Chavarro JE, Turman C,Concas MP, Cordell HJ, Davies G, Eibich P, Eriksson N, Esko T, Eriksson J,Falahi F, Felix JF, Fontana MA, Franke L, Gandin I, Gaskins AJ, Gieger C,Gunderson EP, Guo X, Hayward C, He C, Hofer E, Huang H, Joshi PK, Kanoni S,Karlsson R, Kiechl S, Kifley A, Kluttig A, Kraft P, Lagou V, Lecoeur C, LahtiJ, Li-Gao R, Lind PA, Liu T, Makalic E, Mamasoula C, Matteson L, Mbarek H,McArdle PF, McMahon G, Meddens SF, Mihailov E, Miller M, Missmer SA, MonnereauC, van der Most PJ, Myhre R, Nalls MA, Nutile T, Kalafati IP, Porcu E, ProkopenkoI, Rajan KB, Rich-Edwards J, Rietveld CA, Robino A, Rose LM, Rueedi R, Ryan KA,Saba Y, Schmidt D, Smith JA, Stolk L, Streeten E, Tönjes A, Thorleifsson G,Ulivi S, Wedenoja J, Wellmann J, Willeit P, Yao J, Yengo L, Zhao JH, Zhao W,Zhernakova DV, Amin N, Andrews H, Balkau B, Barzilai N, Bergmann S, Biino G,Bisgaard H, Bønnelykke K, Boomsma DI, Buring JE, Campbell H, Cappellani S,Ciullo M, Cox SR, Cucca F, Toniolo D, Davey-Smith G, Deary IJ, Dedoussis G,Deloukas P, van Duijn CM, de Geus EJ, Eriksson JG, Evans DA, Faul JD, Sala CF,Froguel P, Gasparini P, Girotto G, Grabe HJ, Greiser KH, Groenen PJ, de HaanHG, Haerting J, Harris TB, Heath AC, Heikkilä K, Hofman A, Homuth G, HollidayEG, Hopper J, Hyppönen E, Jacobsson B, Jaddoe VW, Johannesson M, Jugessur A,Kähönen M, Kajantie E, Kardia SL, Keavney B, Kolcic I, Koponen P, Kovacs P,Kronenberg F, Kutalik Z, La Bianca M, Lachance G, Iacono WG, Lai S, LehtimäkiT, Liewald DC; LifeLines Cohort Study, Lindgren CM, Liu Y, Luben R, Lucht M,Luoto R, Magnus P, Magnusson PK, Martin NG, McGue M, McQuillan R, Medland SE,Meisinger C, Mellström D, Metspalu A, Traglia M, Milani L, Mitchell P,Montgomery GW, Mook-Kanamori D, de Mutsert R, Nohr EA, Ohlsson C, Olsen J, OngKK, Paternoster L, Pattie A, Penninx BW, Perola M, Peyser PA, Pirastu M,Polasek O, Power C, Kaprio J, Raffel LJ, Räikkönen K, Raitakari O, Ridker PM,Ring SM, Roll K, Rudan I, Ruggiero D, Rujescu D, Salomaa V, Schlessinger D,Schmidt H, Schmidt R, Schupf N, Smit J, Sorice R, Spector TD, Starr JM, StöcklD, Strauch K, Stumvoll M, Swertz MA, Thorsteinsdottir U, Thurik AR, Timpson NJ,Tung JY, Uitterlinden AG, Vaccargiu S, Viikari J, Vitart V, Völzke H,Vollenweider P, Vuckovic D, Waage J, Wagner GG, Wang JJ, Wareham NJ, Weir DR,Willemsen G, Willeit J, Wright AF, Zondervan KT, Stefansson K, Krueger RF, LeeJJ, Benjamin DJ, Cesarini D, Koellinger PD, den Hoed M, Snieder H, Mills MC (2016): Genome-wide analysis identifies 12 loci influencing human reproductivebehavior. Nature Genetics,48, 1462-1472. •Shen X and Zhan Y (2015): RE: The effect on melanoma risk of genes previously associated with telomere length. Journal of the National Cancer Institute, 107(10): djv237. •AlamM and Ronnegard L and Shen X (2015): Fitting conditional and simultaneous autoregressive spatial models in hglm. The R Journal, 7(2):5-18. •Shen X, Forsberg S, Pettersson M, Sheng Z, and Carlborg O (2014): Natural CMT2 variation is associated with genome-wide methylation changes and temperature seasonality. PLOS Genetics,10(12), e1004842. •Shen X and Hill WG (2014): Opportunities for improvement of phenotypic variability: influence of direct vs epistatic effects. Proceedings of the 10th WCGALP. •RonnegardL, Felleki M, Alam M, and Shen X (2014): Simultaneous estimation of spatial and genetic effects using hierarchical generalized linear models. Proceedings of the 10th WCGALP. •Shen X, Alam M and Ronnegard L (2014): Mixed models through the lens of hglm: applications and grand challenges. JSM Proceedings. •Shen X, Li Y, Ronnegard L, Uden P and Carlborg O (2014): Application of a genomic model in chemometrics analysis. Journal of Chemometrics, 28: 548-557. •Shen X (2013): The curse of the missing heritability. Frontiers in Genetics, 4:225. •Shen X and Ronnegard L (2013): Issues with data transformation in genome-wide association studies for phenotypic variability. F1000Research, 2:200. •Shen X and Carlborg O (2013): Beware of risk for increased false positive rates in genome-wide association studies for phenotypic variability. Frontiers in Genetics, 4:93. •Shen X, Alam M, Fikse F and Ronnegard L (2013): A novel generalized ridge regression method for quantitative genetics. Genetics,193, 1255-1268. •Shen X, PetterssonM, Ronnegard L and Carlborg O (2012): Inheritance beyond plain heritability:variance-controlling genes in Arabidopsis thaliana. PLOS Genetics, 8(8), e1002839. •Shen X, Ronnegard L, and Carlborg O (2011): How to Deal with GenotypeUncertainty in Variance Component Quantitative Trait Loci Analyses. Genetics Research, Cambridge, 93(5),333-342. •Shen X, Ronnegard L, and Carlborg O (2011): Hierarchical likelihood opens a new way of estimating genetic values using dense marker maps. BMC Proceedings, 5(Suppl 3): S14. •Ronnegard L, Shen X and Alam M (2010): hglm: A Package for FittingHierarchical Generalized Linear Models. The R Journal, 2(2):20-28.
1、该研究项目，运用野外与室 内相结合的方法，采用种咱测试手段，取得了较多较多的资料。. 2、对区域成矿地质条件、地层、岩浆岩和构造等进行了不同程度的阐明了它们对区内金矿的控制作用，观点是比较明确的，论说服力，提出了胶东群是金矿的矿源层 ...
4A 上海诗悠国际旅行社有限公司 L-SH-00934 浦东新区 4A 上海港国际邮轮旅行社有限公司 L-SH-01187 虹口区 4A 上海君汇国际旅行社有限公司 L-SH-01255 松江区 3A 上海东泰旅行社有限公司 L-SH-00443 崇明县 ...
根据00934部队1979年在县内勘测的水文地质资料，发现龟石水库内的峡谷左岸岭坡开裂一大滑体，而且继续向前滑动，已采取向左岸和坝基进行固结灌浆等相应的措施。
氡子体诱发肺癌的K取恒定值0.015WLM。. 接受多次，例如两次剂量为D1和D2的照射时使用相互作用的相加模型，其合计相对危险增加为各自相对危险增加之和，即. R (D1,D2)=R (D1)十R (D2) …………………………. (3) 对慢性职业性照射致癌PC的计算也采用这种方法:以年为 ...
《中药别名速查大辞典》是1996年学苑出版社出版的图书，作者是李顺保。
