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  1. 2022年7月29日 · Urinary tract infections (UTIs) are infections of the urethra, bladder, ureters, or kidneys, which comprise the urinary tract. E. coli bacteria cause the majority of UTIs, but many other bacteria, fungi, and parasites may also cause UTIs.

  2. What are common side effects of urinary tract infection and bladder infection medications? Side effects of antibiotics used to treat urinary tract infection and bladder infection include. nausea, diarrhea, dizziness, lightheadedness, headache, or. trouble sleeping. Other severe and less common side effects include.

    • Mechanism of Action
    • Pharmacodynamics
    • Pharmacokinetics
    • Distribution
    • Specific Populations
    • Drug-Drug Interactions
    • Clinical Studies

    Alfuzosin is a selective antagonist of post-synaptic alpha1-adrenoreceptors, which are located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra.

    Alfuzosin exhibits selectivity for alpha adrenergic receptors in the lower urinary tract. Blockade of these adrenoreceptors can cause smooth muscle in the bladder neck and prostate to relax, resulting in an improvement in urine flow and a reduction in symptoms of BPH. The effect of 10 mg and 40 mg alfuzosin on QT interval was evaluated in a double-...

    The pharmacokinetics of UROXATRAL have been evaluated in adult healthy male volunteers after single and/or multiple administration with daily doses ranging from 7.5 mg to 30 mg, and in patients with BPH at doses from 7.5 mg to 15 mg. The absolute bioavailability of UROXATRAL 10 mg tablets under fed conditions is 49%. Following multiple dosing of 10...

    The volume of distribution following intravenous administration in healthy male middle-aged volunteers was 3.2 L/kg. Results of in vitrostudies indicate that alfuzosin is moderately bound to human plasma proteins (82% to 90%), with linear binding over a wide concentration range (5 to 5,000 ng/mL). Alfuzosin undergoes extensive metabolism by the liv...

    In a pharmacokinetic assessment during phase 3 clinical studies in patients with BPH, there was no relationship between peak plasma concentrations of alfuzosin and age. However, trough levels were positively correlated with age. The concentrations in subjects ≥75 years of age were approximately 35% greater than in those below 65 years of age. The P...

    CYP3A4 is the principal hepatic enzyme isoform involved in the metabolism of alfuzosin. Repeated oral administration of 400 mg/day of ketoconazole, a potent inhibitor of CYP3A4, increased alfuzosin Cmax by 2.3-fold and AUClast by 3.2-fold, following a single 10 mg dose of alfuzosin. In another study, repeated oral administration of a lower (200 mg/...

    Three randomized placebo-controlled, double-blind, parallel-arm, 12-week trials were conducted with the 10 mg daily dose of alfuzosin. In these three trials, 1,608 patients [mean age 64.2 years, range 49-92 years; Caucasian (96.1%), Black (1.6%), Asian (1.1%), Other (1.2%)] were randomized and 473 patients received UROXATRAL 10 mg daily. Table 4 pr...

  3. Urinary antispasmodic agents are medications prescribed to treat bladder overactivity which can cause urinary urgency and incontinence. Urinary antispasmodic agents increase bladder capacity, delay the desire to void, decrease the frequency and urgency to urinate, and reduce pain caused by difficulty in urination.

  4. 2023年5月2日 · Uloric (febuxostat) is a xanthine oxidase inhibitor used to treat excess uric acid in the blood ( hyperuricemia) in patients with gout. What Are Side Effects of Uloric? Uloric may cause serious side effects including: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising,

  5. 2022年4月28日 · What Is Luxiq? Luxiq (betamethasone valerate) is a topical corticosteroid used to treat skin conditions of the scalp such as psoriasis or seborrhea (dandruff). What Are Side Effects of Luxiq? Common side effects of Luxiq include: application site reactions (mild burning, stinging, redness, peeling, or itching), thinning of your skin,

  6. 2020年9月9日 · Avodart (dutasteride) is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5 alpha-reductase used to treat benign prostatic hyperplasia ( BPH) in men with an enlarged prostate. Avodart helps improve urinary flow and may also reduce the need for prostate surgery later.

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