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Sympathomimetics stimulate the satiety centers located in the hypothalamic and limbic areas of the brain, thus suppressing the appetite, which may be beneficial in treating obesity. HOW ARE SYMPATHOMIMETICS USED? Sympathomimetics are drugs that act on the brain to suppress appetite for treating obesity. WHAT ARE SIDE EFFECTS OF SYMPATHOMIMETICS?
- Mechanism of Action
- Pharmacodynamics
- Pharmacokinetics
- Drug Interactions
- Chronic Stable Angina
- Lack of Benefit in Acute Coronary Syndrome
The mechanism of action of ranolazine’s antianginal effects has not been determined. Ranolazine has anti-ischemic and antianginal effects that do not depend upon reductions in heart rate or blood pressure. It does not affect the rate-pressure product, a measure of myocardial work, at maximal exercise. Ranolazine at therapeutic levels can inhibit th...
Patients with chronic angina treated with RANEXA in controlled clinical studies had minimal changes in mean heart rate (<2 bpm) and systolic blood pressure (<3 mm Hg). Similar results were observed in subgroups of patients with CHF NYHA Class I or II, diabetes, or reactive airway disease, and in elderly patients. Dose and plasma concentration-relat...
Ranolazine is extensively metabolized in the gut and liver and its absorption is highly variable. For example, at a dose of 1000 mg twice daily, the mean steady-state Cmax was 2600 ng/mL with 95% confidence limits of 400 and 6100 ng/mL. The pharmacokinetics of the (+) R-and (-) S-enantiomers of ranolazine are similar in healthy volunteers. The appa...
In vitrodata indicate that ranolazine is a substrate of CYP3A and, to a lesser degree, of CYP2D6. Ranolazine is also a substrate of P-glycoprotein. Strong CYP3A Inhibitors Plasma levels of ranolazine with RANEXA 1000 mg twice daily are increased by 220% when co-administered with ketoconazole 200 mg twice daily [see CONTRAINDICATIONS]. Moderate CYP3...
CARISA (Combination Assessment of Ranolazine In Stable Angina) was a study in 823 chronic angina patients randomized to receive 12 weeks of treatment with twice-daily RANEXA 750 mg, 1000 mg, or placebo, who also continued on daily doses of atenolol 50 mg, amlodipine 5 mg, or diltiazem CD 180 mg. Sublingual nitrates were used in this study as needed...
In a large (n=6560) placebo-controlled trial (MERLIN-TIMI 36) in patients with acute coronary syndrome, there was no benefit shown on outcome measures. However, the study is somewhat reassuring regarding proarrhythmic risks, as ventricular arrhythmias were less common on ranolazine [see CLINICAL PHARMACOLOGY], and there was no difference between RA...
2022年2月8日 · What Is Codeine Phosphate? Codeine phosphate is an opioid analgesic (pain reliever) drug used to treat many causes of mild to moderate pain. Codeine phosphate is available in generic form. What Are Side Effects of Codeine Phosphate? Common side effects of codeine phosphate include: drowsiness, lightheadedness, dizziness, sedation,
2020年10月16日 · Toradol (ketorolac tromethamine) is a nonsteroidal anti-inflammatory drug ( NSAID) that is used to treat moderately severe pain and inflammation, usually after surgery. Toradol works by blocking the production of prostaglandins, compounds that cause pain, fever, and inflammation.
2021年11月18日 · Dulcolax (bisacodyl) is a stimulant indicated for relief of occasional constipation, and for use under medical supervision, for the preparation of diagnostic procedures, in pre- and treatment, and in conditions which require defecation to be facilitated. Dulcolax is available over-the-counter () without a prescription. laxative postoperative OTC.
Hydralazine is a prescription medication used to treat the symptoms of Severe Essential Hypertension, Chronic Hypertension, Hypertensive Crisis, and Congestive Heart Failure. Hydralazine is available under the following different brand names: Apresoline. What Are Dosages of Hydralazine? Adult and pediatric dosage. Injectable solution. 20mg/mL.
2021年7月7日 · Uses for Kenalog 10 Injection The intra-articular or soft tissue administration of Kenalog-10 Injection (triamcinolone acetonide injectable suspension, USP) is indicated as adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid ...
