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  1. Overview. SAMe is a molecule that is made naturally in the body from homocysteine and folate. It can also be made in a lab and taken in supplements. SAMe is involved in the formation, activation,...

    • Chemistry
    • Medical uses
    • Uses
    • Administration

    SAM-e is a compound that's made naturally in the body and plays an important role in normal bodily function. A synthesized form of SAM-e is considered a supplement in the U.S., but SAM-e has been sold as a prescription drug in parts of Europe for decades. Its scientific name is S-adenosylmethionine. SAM-e is also known as ademetionine and SAMe.

    SAM-e has good evidence as a treatment for osteoarthritis pain. Some studies have found that oral SAM-e is as effective as NSAID painkillers, such as ibuprofen and Celebrex. SAM-e takes longer to act than drugs do, but it also has fewer side effects than NSAIDs.

    SAM-e has also been used to treat depression for many years. Some studies have found that SAM-e might work as well as tricyclic antidepressants in relieving symptoms. However, many of these studies were flawed or too small to be conclusive. Other uses of SAM-e have not been studied as thoroughly. There's some evidence that SAM-e might help ease the...

    There is no established ideal dose of SAM-e. For depression, many studies have used between 800 -1,600 milligrams daily. For osteoarthritis, 600-1,200 milligrams daily of SAM-e divided into three doses is common. Ask your doctor for advice. Sometimes, the dose of SAM-e is increased gradually over a few weeks. This can help reduce side effects such ...

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