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  1. 3 天前 · Volnea (desogestrel and ethinyl estradiol kit) tablets are a combined oral contraceptive (COC) indicated for the prevention of pregnancy in women who elect to use this product as a method of contraception. What Are Side Effects of Volnea? Side effects of Volnea include: nausea, vomiting,

    • Mechanism of Action
    • Pharmacodynamics
    • Pharmacokinetics
    • Deficiency of IL-1 Receptor Antagonist
    • Recurrent Pericarditis

    Rilonacept is an interleukin-1 alpha (IL-1α) and interleukin-1 beta (IL-1β) cytokine trap. Rilonacept blocks IL-1 signaling by acting as a soluble decoy receptor that binds both IL-1α and IL-1β and prevents its interaction with cell surface receptors. Rilonacept also binds interleukin-1 receptor antagonist (IL-1ra). The equilibrium dissociation con...

    C-Reactive Protein (CRP) and Serum Amyloid A (SAA) are indicators of inflammatory disease activity that are elevated in patients with CAPS. Elevated SAA has been associated with the development of systemic amyloidosisin patients with CAPS. Compared to placebo, treatment with ARCALYST resulted in sustained reductions from baseline in mean serum CRP ...

    The average trough levels of rilonacept were approximately 24 mcg/mL at steady state following weekly subcutaneous doses of 160 mg for up to 48 weeks in patients with CAPS. The steady state appeared to be reached by 6 weeks. The average trough levels of rilonacept were approximately 23 mcg/mL at steady state, and the circulationhalf-life in vivo wa...

    The safety and efficacy of ARCALYST for the maintenance of remission of DIRA were demonstrated in a 2-year, open-label study (NCT01801449) of 6 pediatric patients who previously experienced clinical benefit from daily injections of an IL-1 receptor antagonist, anakinra. The study populationincluded patients with a loss-of-function IL1RN mutations. ...

    The efficacy and safety of ARCALYST were evaluated in the Phase 3 study RHAPSODY (NCT03737110), a double-blind, placebo-controlled, randomized withdrawal, multinational study. The study consisted of a 12-week run-in followed by a double-blind, placebo-controlled, randomized withdrawal period. In the run-in period, adult patients received a loading ...

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