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Simaruba is a plant that grows in the Caribbean islands and in the northern parts of South America. The bark is used as medicine. People take simaruba for diarrhea, dysentery, malaria, water retention (edema), fever, and stomach upset. It is also used as a tonic. Women use it to cause abortion. How does work?
- Dizziness, Somnolence, Mental Status Changes, and Gait Disturbances
- Risk of Driving and Operating Machinery
- Carcinogenesis, Mutagenesis, Impairment of Fertility
- Pregnancy
- Lactation
- Geriatric Use
- Hepatic Impairment
Dizziness, somnolence, mental status changes, and gait disturbances, including falls, have occurred in patients taking KORSUVA and may subside over time with continued treatment [see ADVERSE REACTIONS]. In Trial 1 and Trial 2, 17.0% of patients randomized to receive KORSUVA reported at least one of these adverse reactions, compared to 12.0% of pati...
Dizziness, somnolence, and mental status changes have occurred in patients taking KORSUVA. KORSUVA may impair the mental or physical abilities needed to perform potentially hazardous activities such as driving a car and operating machinery. Advise patients not to drive or operate dangerous machinery until the effect of KORSUVA on a patient’s abil...
In a 2-year carcinogenicity study in rats, difelikefalin was not carcinogenic when administered via subcutaneous injection at doses up to 1.0 mg/kg/day (597 times the MRHD based on AUC comparison). Difelikefalin was not carcinogenic in a 6-month carcinogenicity study in transgenic rasH2 mice at subcutaneous doses up to 30 mg/kg/day. Difelikefalin w...
The limited human data on use of KORSUVA in pregnant women are not sufficient to evaluate a drug-associated risk for major birth defects or miscarriage. In animal reproduction studies, intravenous injection of difelikefalin to pregnant rats and rabbits during the period of organogenesis at doses 711 and 10 times the maximum recommended human dose (...
There are no data regarding the presence of KORSUVA in human milk or effects on the breastfed infant or on milk production. Studies in rats showed difelikefalin was transferred into the milk in lactating rats. When a drug is present in animal milk, it is likely that the drug will be present in human milk. The developmental and health benefits of br...
Of the 848 subjects in the placebo-controlled studies who received KORSUVA, 278 subjects (32.8%) were 65 years of age and older and 98 subjects (11.6%) were 75 years of age and older. No overall differences in safety or effectiveness of KORSUVA have been observed between patients 65 years of age and older and younger adult subjects, with the except...
The influence of mild-to-moderate hepatic impairment on the pharmacokinetics of KORSUVA was evaluated in a population pharmacokinetic analysis which concluded that no KORSUVA dosage adjustments are needed in these populations [see CLINICAL PHARMACOLOGY]. The influence of severe hepatic impairment on the pharmacokinetics of KORSUVA in subjects under...
2023年5月18日 · Drug Summary. What Is Artane? Artane (trihexyphenidyl) is an antispasmodic drug used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. Artane is also used to treat and prevent the same muscular conditions when they are caused by certain drugs. What Are Side Effects of Artane? Side effects of Artane include:
2017年1月19日 · Fansidar (sulfadoxine and pyrimethamine) Tablets is an antiparasitic drug used to treat malaria. Fansidar is available in generic form. Common side effects of Fansidar include: stomach pain, feeling full, hair loss, headache, muscle weakness, depression, nervousness, ringing in your ears, sleep problems (insomnia), diarrhea, dizziness, nausea,
2022年7月18日 · Hydrocodone is a prescription narcotic indicated for the management of pain severe enough to require daily, around-the-clock, long-term treatment and for which alternative treatment options are inadequate. Hydrocodone is available under the following different brand names: Zohydro ER, Hysingla ER, and Vantrela ER.
2022年10月18日 · Giazo (balsalazide disodium) is an anti-inflammatory drug indicated for the treatment of mildly to moderately active ulcerative colitis in male patients 18 years of age and older. Giazo is available in a generic form termed balsalazide. What Are Side Effects of Giazo? Giazo may cause serious side effects including: hives, difficulty breathing,
2021年4月12日 · What Is Twynsta? Twynsta (telmisartan/amlodipine) is a combination of an angiotensin receptor blocker and a calcium channel blocker used to treat high blood pressure ( hypertension ). What Are Side Effects of Twynsta? Common side effects of Twynsta include: dizziness or lightheadedness as your body adjusts to the medication.
