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Immune globulin IV (IGIV) is a prescription medication used to treat the symptoms of Primary Immunodeficiency Syndrome, Immune Thrombocytopenic Purpura, Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Bone Marrow Transplant, B-cell Chronic Lymphocytic Leukemia, and Multifocal Motor Neuropathy.
Indicated to prevent or modify measles (rubeola) in a susceptible person exposed fewer than 6 days previously. Also indicated for susceptible household contacts of measles patients, particularly contacts under 1 year and pregnant women without evidence of immunity. Postexposure prophylaxis.
- Sensitivity
- Renal Failure
- Blood Glucose Monitoring
- Hyperproteinemia
- Thrombotic Events
- Aseptic Meningitis Syndrome
- Hemolysis
- Transfusion-Related Acute Lung Injury
- General
- Laboratory Tests
Severe hypersensitivity reactions may occur (SeeCONTRAINDICATIONS). In case of hypersensitivity, Octagam 5% liquid infusionshould be immediately discontinued and appropriate treatment instituted. Epinephrine should be immediately available for treatment of acute severehypersensitivity reaction. IgA deficient patients with antibodies against IgAare ...
Assure that patients are not volume depleted prior to theinitiation of the infusion of Octagam 5% liquid. Periodic monitoring of renal function tests and urineoutput is particularly important in patients judged to have a potentialincreased risk of developing acute renal failure. Renal function, including ameasurement of blood urea nitrogen (BUN)/se...
Blood Glucose Testing : some types of blood glucosetesting systems (for example, those based on the glucose dehydrogenasepyrroloquinolinequinone (GDH-PQQ) or glucose-dye-oxidoreductase methods)falsely interpret the maltose contained in Octagam 5% liquid as glucose. Thishas resulted in falsely elevated glucose readings and, consequently, in theinapp...
Hyperproteinemia, increased serum viscosity and hyponatremia may occur in patients receiving IGIV therapy. The hyponatremia islikely to be a pseudohyponatremia as demonstrated by a decreased calculatedserum osmolality or elevated osmolargap. Distinguishing true hyponatremia frompseudohyponatremia is clinically critical, as treatment aimed at decrea...
Thrombosis may occur following treatment with immuneglobulin products, including Octagam 5% liquid. Risk factors may include:advanced age, prolonged immobilization, hypercoagulable conditions, history of venousor arterial thrombosis, use of estrogens, indwelling central vascular catheters, hyperviscosity, and cardiovascularrisk factors. Thrombosis ...
Aseptic meningitis syndrome (AMS) has been reported tooccur infrequently in association with IGIV treatment. Discontinuation of IGIVtreatment has resulted in remission of AMS within several days without sequelae. The syndrome usually begins within several hours to two daysfollowing IGIV treatment and rapid infusion. It is characterized by symptomsa...
IGIV products can contain blood group antibodies whichmay act as hemolysins and induce in vivo coating of red blood cells with immunoglobulin, causing a positive direct antiglobulin reaction and, rarely, hemolysis . Hemolytic anemia can develop subsequent to IGIV therapy due toenhanced RBC sequestration [SeeADVERSE REACTIONS] . IGIV recipientsshoul...
There have been reports of noncardiogenic pulmonary edema [Transfusion-Related Acute Lung Injury (TRALI)] in patients administered IGIV. TRALI is characterized by severe respiratory distress, pulmonary edema, hypoxemia,normal left ventricularfunction, and fever and typically occurs within 1-6hours after transfusion. Patients with TRALI may be manag...
Because this product is made from human blood, it maycarry a risk of transmitting infectious agents, e.g., viruses andtheoretically, the Creutzfeldt-Jakob disease (CJD) agent. All infectionsthought by a physician possibly to have been transmitted by this product shouldbe reported by the physician or other healthcare provider to Octapharma. Thephysi...
If signs and/or symptoms of hemolysis are present afterIGIV infusion, appropriate confirmatory laboratory testing should be done. If TRALI is suspected, appropriate tests should beperformed for the presence of anti-neutrophil antibodies in both the productand patient serum. Because of the potentially increased risk of thrombosis,baseline assessment...
2022年6月14日 · Gammaplex (immune globulin intravenous [human], 5% liquid) is an immune globulin intravenous (human) 5% liquid indicated for the treatment of primary humoral immunodeficiency (PI) in adults and pediatric patients two years of age and older and for the treatment of chronic immune thrombocytopenic purpura (ITP).
I (f) current inhibitors or I funny current inhibitors are drugs that lower heart rates and are used in the treatment of angina (a type of chest pain caused by reduced blood flow to the heart).
Repatha (evolocumab) Injection is a human monoclonal immunoglobulin G2 (IgG2) as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic lipoprotein
Cytogam [ Cytomegalovirus Immune Globulin Intravenous (Human)] is a sterilized solution obtained from pooled human blood that contains the immunoglobulins (or antibodies) to protect against infection from cytomegalovirus and is used to help prevent infection by cytomegalovirus in people who receive an organ transplant.
