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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red). Proteins are large biomolecules and ...
Ionization and Brønsted character of N-terminal amino, C-terminal carboxylate, and side chains of amino acid residues The common natural forms of amino acids have a zwitterionic structure, with −NH + 3 (−NH + 2 − in the case of proline) and −CO − 2 functional groups attached to the same C atom, and are thus α-amino acids, and are the only ones found in proteins during translation ...
- Family Members - Isoforms
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There are three different genes that encode isoforms of Protein kinase B. These three genes are referred to as AKT1, AKT2, and AKT3 and encode the RAC alpha, beta, and gamma serine/threonine protein kinases respectively. The terms PKB and Aktmay refer to the products of all three genes collectively, but sometimes are used to refer to PKB alpha and ...
The name Akt does not refer to its function. The "Ak" in Akt refers to the AKR mouse strain that develops spontaneous thymic lymphomas. The "t" stands for 'thymoma'; the letter was added when a transforming retrovirus was isolated from the Ak mouse strain, which was termed "Akt-8". The authors state, "Stock A Strain k AKR mouse originally inbred in...
The Akt kinases regulate cellular survival and metabolism by binding and regulating many downstream effectors, e.g. Nuclear Factor-κB, Bcl-2 family proteins, master lysosomal regulator TFEB and murine double minute 2 (MDM2).
Akt proteins are associated with tumor cell survival, proliferation, and invasiveness. The activation of Akt is also one of the most frequent alterations observed in human cancer and tumor cells. Tumor cells that have constantly active Akt may depend on Akt for survival.Therefore, understanding the Akt proteins and their pathways is important for t...
Ludwigsburg Palace is a 452-room complex of 18 buildings in Ludwigsburg, Baden-Württemberg, Germany. It is the largest palatial estate in the country and has been called the " Versailles of Swabia ". Eberhard Louis, Duke of Württemberg, began construction of the palace in 1704. Charles Eugene, the son of his successor, completed it and ...
Below are two tables which report the average adult human height by country or geographical region. With regard to the first table, original studies and sources should be consulted for details on methodology and the exact populations measured, surveyed, or considered. With regard to the second table, these estimated figures for adult human ...
American retail corporation Walmart has been the world's largest company by revenue since 2014. [1] The list is limited to the largest 50 companies, all of which have annual revenues exceeding US$130 billion. This list is incomplete, as not all companies disclose their information to the media and/or general public. [3]
Wikipedia is a free content online encyclopedia written and maintained by a community of volunteers, known as Wikipedians, through open collaboration and the wiki software MediaWiki.Wikipedia is the largest and most-read reference work in history, and is consistently ranked among the ten most visited websites; as of April 2024, it was ranked fourth by Semrush, and seventh by Similarweb.
