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Hydroxychloroquine is an antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus. Brand Names. Plaquenil, Sovuna. Generic Name. Hydroxychloroquine.
2020年2月7日 · Key points. The DMARDs hydroxychloroquine and chloroquine are weak bases that accumulate in acidic compartments such as lysosomes and inflamed (acidic) tissues. Both hydroxychloroquine and...
羥氯奎寧 （英語： hydroxychloroquine ，縮寫：HCQ），在 台灣 稱作 羥氯奎寧 、 氫氧奎寧 ，或長期被簡稱 奎寧 （雖然嚴格而言，兩者化學成份並不相同）。. 羥氯奎寧的口服 [2] 形式為硫酸羥氯奎寧（hydroxychloroquine sulfate），較為人熟知的商品名為 必賴克瘻 (英語 ...
Hydroxychloroquine increases lysosomal pH in antigen-presenting cells by two mechanisms: As a weak base, it is a proton acceptor and via this chemical interaction, its accumulation in lysozymes raises the intralysosomal pH, but this mechanism does not
This chapter covers the pharmacology of chloroquine and hydroxychloroquine, which is similar for both drugs [ 1 ], but the details are different. For example, both drugs are partially excreted in feces, but the proportions differ slightly—8–10 % for chloroquine and 15–24 % for hydroxychloroquine.
Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases, insights into the mechanism of
2020年11月2日 · The review is an in-depth analysis of the antimalarial, immunomodulatory, and antiviral mechanisms of hydroxychloroquine, with detailed and novel pictorial explanations. The mechanisms of hydroxychloroquine are related to potential cardiotoxic manifestations
