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What Is Oxybutynin and How Does It Work? Oxybutynin is indicated for the relief of symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (i.e., urgency, frequency, urinary leakage, urge incontinence, dysuria ).
- Mechanism of Action
- Pharmacodynamics
- Pharmacokinetics
- Specific Populations
- Drug Interaction Studies
- Animal Toxicology
- Clinical Studies
- Management of Hyperuricemia in Gout
- Cardiovascular Safety Study
ULORIC,a xanthine oxidase inhibitor, achieves its therapeutic effectbydecreasing serum uric acid. ULORIC is not expected to inhibit other enzymes involved in purine and pyrimidine synthesis and metabolism at therapeutic concentrations.
In healthy patients, ULORIC resulted in a dose dependent decrease in 24-hour mean serum uric acid concentrations and an increase in 24-hour mean serum xanthine concentrations. In addition, there was a decrease in the total daily urinary uric acid excretion. Also, there was an increase in total daily urinary xanthine excretion. Percent reduction in ...
In healthy patients, maximum plasma concentrations (Cmax) and AUC of febuxostat increased in a dose proportional manner following single and multiple doses of 10 mg (0.25 times the lowest recommended dosage) to 120 mg (1.5 times the maximum recommended dosage). There is no accumulation when therapeutic doses are administered every 24 hours. Febuxos...
The Cmax and AUC of febuxostat and its metabolites following multiple oral doses of ULORIC in geriatric patients (≥65 years) were similar to those in younger patients (18 to 40 years). In addition, the percent decrease in serum uric acid concentration was similar between elderly and younger patients. No dose adjustment is necessary in geriatric pat...
Xanthine Oxidase Substrate Drugs-Azathioprine, Mercaptopurine, and Theophylline Febuxostat is an XO inhibitor. A drug-drug interaction study evaluating the effectof ULORIC upon the pharmacokinetics of theophylline (an XO substrate) in healthy patients showed that coadministration of febuxostat with theophylline resulted in an approximately 400-fold...
A 12-month toxicity study in beagle dogs showed deposition of xanthine crystals and calculi in kidneys at15mg/kg (approximately4times theMRHD on an AUC basis). Asimilar effect of calculus formation was noted in rats in a 6-month study due to deposition of xanthine crystals at 48 mg/kg (approximately 31 and 40 times the MRHD on an AUC basis in males...
A serum uric acid level of less than 6 mg/dL is the goal of antihyperuricemic therapy and has been established as appropriate for the treatment of gout.
The efficacy of ULORIC was demonstrated in three randomized, double-blind, controlled trials in patients with hyperuricemia and gout. Hyperuricemia was defined as a baseline serum uric acid level ≥8 mg/dL. Study 1 (NCT00430248) randomized patients to: ULORIC 40 mg daily, ULORIC 80 mg daily, or allopurinol (300 mg daily for patients with estimated c...
A randomized, double-blind, allopurinol-controlled CV outcomes study (CARES) was conducted to evaluate the CV risk of ULORIC (NCT01101035). The study compared the risk of MACE between patients treated with ULORIC (N=3098) and allopurinol-treated patients (N=3092). The primary endpoint was the time to first occurrence of a MACE defined as the compos...
2017年12月4日 · Innohep (tinzaparin) is a blood thinner ( anticoagulant) used together with warfarin ( Coumadin) to treat a type of blood clot called deep vein thrombosis, or DVT. This condition sometimes occurs with a blood clot in lungs ( pulmonary embolism, or PE). Common side effects of Innohep include:
2022年6月14日 · Modurectic (amiloride HCl-hydrochlorothiazide) is a combination of a potassium -conserving (antikaliuretic) drug and a diuretic indicated in those patients with hypertension, or with congestive heart failure who develop low blood potassium ( hypokalemia) when thiazides or other kaliuretic diuretics are used, or in whom maintenance of normal seru...
2021年6月28日 · Common side effects of Zadaxin include. redness and discomfort at the injection site, muscle atrophy, multiple joint aches and pains, and. swelling and rash of the hand. Dosage for Zadaxin. The recommended dosage of Zadaxin is 1.6 mg (900 µg/m2) twice a week for 6 to 12 months. What Drugs, Substances, or Supplements Interact with Zadaxin?
2017年1月25日 · Periostat ( doxycycline hyclate) is a tetracycline antibiotic indicated for use as an adjunct to dental procedures including scaling and root planning to promote attachment level gain and to reduce pocket depth in patients with adult periodontitis. Side effects of Periostat include: severe headache, dizziness, blurred vision, nausea, diarrhea,
What Is Aloprim? Aloprim (allopurinol sodium) for Injection is a xanthine oxidase inhibitor used to manage patients with leukemia, lymphoma, and solid tumor malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels and who cannot tolerate oral therapy. Aloprim is available in generic form.
