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Benadryl (diphenhydramine) and Zyrtec (cetirizine hydrochloride) are antihistamines used to treat allergy symptoms, such as itching, hives, runny nose, watery eyes, and sneezing from hay fever ( allergic rhinitis) and other allergies, such as allergies to molds and dust mites. Benadryl is also used to treat insomnia, motion sickness, and mild ...
2022年12月30日 · Here are the antimalarial drugs and their functions. Artemether/lumefantrine: Inhibits nucleic acid and protein synthesis and the parasite through endoperoxide or possibly by inhibiting beta-hematin formation. Artesunate: Contains endoperoxide bridge activated by heme iron and leads to oxidative stress; it inhibits protein and nucleic acid ...
- Addiction, Abuse, and Misuse
- Life-Threatening Respiratory Depression
- Risks from Concomitant Use with Benzodiazepines Or Other CNS Depressants
- Neonatal Opioid Withdrawal Syndrome
- Opioid Analgesic Risk Evaluation and Mitigation Strategy
- Opioid-Induced Hyperalgesia and Allodynia
- Adrenal Insufficiency
- Severe Hypotension
- Risks of Use in Patients with Gastrointestinal Conditions
- Increased Risk of Seizures in Patients with Seizure Disorders
OXYCONTIN contains oxycodone, a Schedule II controlled substance. As an opioid, OXYCONTIN exposes users to the risks of addiction, abuse, and misuse. Because extended-release products such as OXYCONTIN deliver the opioid over an extended period of time, there is a greater risk for overdose and death due to the larger amount of oxycodone present [se...
Serious, life-threatening, or fatal respiratory depression has been reported with the use of opioids, even when used as recommended. Respiratory depression, if not immediately recognized and treated, may lead to respiratory arrest and death. Management of respiratory depression may include close observation, supportive measures, and use of opioid a...
Profound sedation, respiratory depression, coma, and death may result from concomitant use of OXYCONTIN with benzodiazepines and/or other CNS depressants, including alcohol (e.g., nonbenzodiazepines sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, other opioids). Because of these risks, reserve...
Use of OXYCONTIN for an extended period of time during pregnancy can result in withdrawal in the neonate. Neonatal opioid withdrawal syndrome, unlike opioid withdrawal syndrome in adults, may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. Observe newborns for signs...
To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse, and misuse, the Food and Drug Administration (FDA) has required a Risk Evaluation and Mitigation Strategy (REMS) for these products. Under the requirements of the REMS, drug companies with approved opioid analgesic products must make REMS-compliant education pr...
Opioid-Induced Hyperalgesia (OIH) occurs when an opioid analgesic paradoxically causes an increase in pain, or an increase in sensitivity to pain. This condition differs from tolerance, which is the need for increasing doses of opioids to maintain a defined effect [see Dependence]. Symptoms of OIH include (but may not be limited to) increased level...
Cases of adrenal insufficiency have been reported with opioid use, more often following greater than one month of use. Presentation of adrenal insufficiency may include non-specific symptoms and signs including nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure. If adrenal insufficiency is suspected, confirm the diagno...
OXYCONTIN may cause severe hypotension, including orthostatic hypotension and syncope in ambulatory patients. There is an increased risk in patients whose ability to maintain blood pressure has already been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (e.g., phenothiazines or general anesthetics...
OXYCONTIN is contraindicated in patients with known or suspected gastrointestinal obstruction, including paralytic ileus. The oxycodone in OXYCONTIN may cause spasm of the sphincter of Oddi. Opioids may cause increases in the serum amylase. Regularly evaluate patients with biliary tract disease, including acute pancreatitis, for worsening symptoms.
The oxycodone in OXYCONTIN may increase the frequency of seizures in patients with seizure disorders and may increase the risk of seizures occurring in other clinical settings associated with seizures. Regularly evaluate patients with a history of seizure disorders for worsened seizure control during OXYCONTIN therapy.
blurred vision, dry mouth, changes in appetite or weight, decreased sex drive, impotence, difficulty having an orgasm, increased blood pressure, and. seizures. Abrupt discontinuation of Effexor may cause dizziness, headache, nausea, changes in mood, or changes in the sense of smell, and taste.
2023年6月6日 · The usual starting dose of COZAAR is 50 mg once daily. The dosage can be increased to a maximum dose of 100 mg once daily as needed to control blood pressure [see Clinical Studies] . A starting dose of 25 mg is recommended for patients with possible intravascular depletion (e.g., on diuretic therapy).
2023年9月7日 · Adults. The usual adult dose is one 500-mg tablet of AUGMENTIN every 12 hours or one 250-mg tablet of AUGMENTIN every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be one 875-mg tablet of AUGMENTIN every 12 hours or one 500-mg tablet of AUGMENTIN every 8 hours.
Medications and prescription drug information for consumers and medical health professionals. Online database of the most popular drugs and their side effects, interactions, and use. Featured Centers What Are the Best PsA Treatments for You? Understanding
