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Medications and prescription drug information for consumers and medical health professionals. Online database of the most popular drugs and their side effects, interactions, and use. Addictions and Substance Abuse (Sensitive Topic) RiVive (Naloxone
A drug interaction can be defined as an interaction between a drug and another substance that prevents the drug from performing as expected. This definition applies to interactions of drugs with other drugs (drug-drug interactions), as well as drugs with food (drug-food interactions) and other substances. How do drug interactions occur?
- Hepatotoxicity
- Interstitial Lung Disease (Ild)/Pneumonitis
- Renal Impairment
- Bradycardia
- Severe Myalgia and Creatine Phosphokinase (CPK) Elevation
- Hemolytic Anemia
- Embryo-Fetal Toxicity
- Patient Counseling Information
- Carcinogenesis, Mutagenesis, Impairment of Fertility
- Pregnancy
Elevations of AST greater than 5 times the upper limit of normal (ULN) occurred in 4.6% of patients, and elevations of ALT greater than 5 times the ULN occurred in 5.3% of the 405 patients in Studies NP28761, NP28673 and ALEX who received ALECENSA at a dose of 600 mg BID. Elevations of bilirubin greater than 3 times the ULN occurred in 3.7% of pati...
ILD/pneumonitis occurred in three (0.7%) patients treated with ALECENSA in Studies NP28761, NP28673 and ALEX. One (0.2%) of these events was severe (Grade 3). Promptly investigate for ILD/pneumonitis in any patient who presents with worsening of respiratory symptoms indicative of ILD/pneumonitis (e.g., dyspnea, cough, and fever). Immediately withho...
Renal impairment occurred in 8% of patients in Studies NP28761, NP28673, and ALEX. The incidence of Grade ≥ 3 renal impairment was 1.7%, of which 0.5% were fatal events. Dose modifications for renal impairment were required in 3.2% of patients. Median time to Grade ≥ 3 renal impairment was 3.7 months (range 0.5 to 14.7 months). Permanently disconti...
Symptomatic bradycardia can occur with ALECENSA. Cases of bradycardia (8.6%) have been reported in patients treated with ALECENSA in Studies NP28761, NP28673 and ALEX. Eighteen percent of 365 patients treated with ALECENSA for whom serial ECGs were available had heart rates of less than 50 beats per minute (bpm). Monitor heart rate and blood pressu...
Myalgia or musculoskeletal pain occurred in 26% of patients in Studies NP28761, NP28673 and ALEX. The incidence of Grade 3 myalgia/musculoskeletal pain was 0.7%. Dose modifications for myalgia/musculoskeletal pain were required in 0.5% of patients. Elevations of CPK occurred in 41% of 347 patients with CPK laboratory data available in Studies NP287...
Hemolytic anemia has been reported with ALECENSA, including cases associated with a negative direct antiglobulin test (DAT) result. If hemolytic anemia is suspected, withhold ALECENSA and initiate appropriate laboratory testing. If hemolytic anemia is confirmed, consider resuming at a reduced dose upon resolution or permanently discontinue ALECENSA...
Based on findings from animal studies and its mechanism of action, ALECENSA can cause fetal harm when administered to pregnant women. Administration of alectinib to pregnant rats and rabbits during the period of organogenesis resulted in embryo-fetal toxicity and abortion at maternally toxic doses with exposures approximately 2.7 times those observ...
Advise the patient to read the FDA-approved patient labeling (PATIENT INFORMATION). Inform patients of the following: Inform patients of the signs and symptoms of bilirubin and hepatic transaminase elevations. Advise patients to contact their healthcare provider immediately for signs or symptoms of bilirubin and hepatic transaminase elevations [see...
Carcinogenicity studies with alectinib have not been conducted. Alectinib was not mutagenic in vitroin the bacterial reverse mutation (Ames) assay, but was positive with an increased number of micronuclei in a rat bone marrow micronucleus test. The mechanism of micronucleus induction was abnormal chromosome segregation (aneugenicity) and not a clas...
Based on animal studies and its mechanism of action, ALECENSA can cause fetal harm when administered to a pregnant woman [see CLINICAL PHARMACOLOGY]. There are no available data on ALECENSA use in pregnant women. Administration of alectinib to pregnant rats and rabbits by oral gavage during the period of organogenesis resulted in embryo-fetal toxic...
2022年8月17日 · Allegra (fexofenadine hydrochloride) is an antihistamine used to treat allergic symptoms of seasonal allergic rhinitis, including: sneezing, runny nose, itchy or watery eyes, and. urticaria (hives) Allegra is available as a generic drug. What Are Side Effects of Allegra? Common side effects of Allegra include: nausea, diarrhea, upset stomach,
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2021年4月23日 · Lotensin (benazepril hydrochloride) is an angiotensin -converting enzyme (ACE) inhibitor used to treat patients with high blood pressure ( hypertension ). Lotensin is available in generic form. What Are Side Effects of Lotensin? Common side effects of Lotensin are: dizziness, cough, headache, nausea, vomiting, constipation, drowsiness, dizziness,
2023年8月16日 · Drug Summary. What Is Trelegy Ellipta? Trelegy Ellipta (fluticasone furoate, umeclidinium, and vilanterol inhalation powder), for oral inhalation is used to treat chronic obstructive pulmonary disease ( COPD ), including chronic bronchitis, and/or emphysema . What Are Side Effects of Trelegy Ellipta?
