metformin 乳酸中毒 相關
廣告Metformin, Works well in lab, HPLC & NMR Verified, 2000+ Selleck Citations Yearly. Metformin, Purity 99.99%, In Stock, Overnight Delivery, Free Delivery.
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What is metformin used for?
Does metformin cause high blood lactic acid level?
Why was phenformin discontinued?
What is Empagliflozin/linagliptin/metformin?
Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type 2 diabetes,[12][13][14][15] particularly in people who are overweight.[13] It is also used in the treatment of polycystic ovary syndrome.[14] It is sometimes used as an off-label adjunct to lessen the risk of metabolic ...
- C₄H₁₁N₅
- AU: C
- Not by liver
- Fortamet, Glucophage, Glumetza, others
Metabolic acidosis is a serious electrolyte disorder characterized by an imbalance in the body's acid-base balance. Metabolic acidosis has three main root causes: increased acid production, loss of bicarbonate, and a reduced ability of the kidneys to excrete excess acids.[5] Metabolic acidosis can lead to acidemia, which is defined as arterial ...
- Acute: Excessive amounts of organic acids;, Chronic: Impaired kidney function
- Acute Metabolic Acidosis, Chronic Metabolic Acidosis
- Level of bicarbonate (HCO3-) in the blood
- Nephrology
Metformin: this risk is low (less than 10 cases for 100,000 patient years), but the risk of metformin-induced lactic acidosis (MALA) increases in certain situations where both the plasma levels of metformin are increased and lactate clearance is impaired.
Pioglitazone/metformin should not be used in people with type 1 diabetes or for the treatment of diabetic ketoacidosis and should be used with caution in people with edema. Serum ALT levels should be evaluated prior to the initiation of therapy with combination of pioglitazone and metformin and periodically thereafter per the clinical judgment of the health care professional.
- Actoplus Met, Piomet, Politor, others
- Thiazolidinedione
Adverse effects To lessen the risk of developing ketoacidosis (a serious condition in which the body produces high levels of blood acids called ketones) after surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes ...
- Trijardy XR
- DPP-4 inhibitor
Canagliflozin/metformin was approved for medical use in the European Union in April 2014, and for use in the United States in August 2014. Medical uses Canagliflozin/metformin is indicated in adults aged 18 years of age and older with type 2 diabetes as an ...
Phenformin. Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases. Phenformin was developed in 1957 by Ungar, Freedman and Seymour Shapiro, working for the US Vitamin Corporation.
