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    • Suppressing activation of Toll-like receptors

      Hydroxychloroquine: An old drug with new relevance
      • The primary mechanism by which hydroxychloroquine modulates systemic lupus erythematosus is by suppressing activation of Toll-like receptors, which exist on the surface of endosomes and play a significant role in the innate immune response and in autoimmune disease.
      www.ccjm.org/content/85/6/459

      Hydroxychloroquine: An old drug with new relevance

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  3. go.drugbank.com › drugs › DB01611Hydroxychloroquine: Uses, Interactions, Mechanism of Action ...

    Hydroxychloroquine is an antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus. Brand Names. Plaquenil, Sovuna. Generic Name. Hydroxychloroquine.

  4. www.nature.com › articles › s41584/020/0372-xMechanisms of action of hydroxychloroquine and chloroquine: ...

    2020年2月7日 · Key points. The DMARDs hydroxychloroquine and chloroquine are weak bases that accumulate in acidic compartments such as lysosomes and inflamed (acidic) tissues. Both hydroxychloroquine and...

    • Eva Schrezenmeier, Thomas Dörner
    • 2020

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  6. zh.wikipedia.org › zh-tw › 羟氯喹羥氯奎寧 - 維基百科，自由的百科全書

    羥氯奎寧 （英語： hydroxychloroquine ，縮寫：HCQ），在 台灣 稱作 羥氯奎寧 、 氫氧奎寧 ，或長期被簡稱 奎寧 （雖然嚴格而言，兩者化學成份並不相同）。. 羥氯奎寧的口服 [2] 形式為硫酸羥氯奎寧（hydroxychloroquine sulfate），較為人熟知的商品名為 必賴克瘻 (英語 ...

  7. en.wikipedia.org › wiki › HydroxychloroquineHydroxychloroquine - Wikipedia

    Hydroxychloroquine increases lysosomal pH in antigen-presenting cells by two mechanisms: As a weak base, it is a proton acceptor and via this chemical interaction, its accumulation in lysozymes raises the intralysosomal pH, but this mechanism does not

  8. www.ncbi.nlm.nih.gov › pmc › articlesPharmacology of Chloroquine and Hydroxychloroquine - PMC

    This chapter covers the pharmacology of chloroquine and hydroxychloroquine, which is similar for both drugs [ 1 ], but the details are different. For example, both drugs are partially excreted in feces, but the proportions differ slightly—8–10 % for chloroquine and 15–24 % for hydroxychloroquine.

    • David J. Browning
    • 2014 Apr
    • 10.1007/978-1-4939-0597-3_2

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    • Hydroxychloroquine's mechanism of action on B cell activation The blue ...
    • Frontiers | Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine
    • Frontiers | Hydroxychloroquine as a Chemoprophylactic Agent for COVID ...
    • Chloroquine & Hydroxychloroquine: Mechanism of Action - AllDayChemist

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  10. pubmed.ncbi.nlm.nih.gov › 32034323Mechanisms of action of hydroxychloroquine and chloroquine: ...

    Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory rheumatic diseases, insights into the mechanism of

  11. www.ncbi.nlm.nih.gov › pmc › articlesHydroxychloroquine: a comprehensive review and its ...

    2020年11月2日 · The review is an in-depth analysis of the antimalarial, immunomodulatory, and antiviral mechanisms of hydroxychloroquine, with detailed and novel pictorial explanations. The mechanisms of hydroxychloroquine are related to potential cardiotoxic manifestations

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    Discoveries That Shape Lives - Digital Collections - Acclaimed Museum

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    We Share The Stories Of The Innovators & Scientific Discoveries That Shape Our Lives. Learn About The History Of Chemistry, Chemical Engineering, & The Life Sciences!

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