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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices. This protein was the first to have its structure solved by X-ray crystallography. Toward the right-center among the coils, a prosthetic group called a heme group (shown in gray) with a bound oxygen molecule (red). Proteins are large biomolecules and ...
Structure of a typical L-alpha-amino acid in the "neutral" form Amino acids are organic compounds that contain both amino and carboxylic acid functional groups.[1] Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins.[2] Only these 22 appear in the genetic code of life.[3 ...
- Uses
- Health Effects
- Available Forms and Nomenclature
- Production
- Safety
- See Also
Medical uses
1. Pharmaceutical-grade PEG is used as an excipientin many pharmaceutical products, in oral, topical, and parenteral dosage forms. 2. PEG is the basis of a number of laxatives (as MiraLax, RestoraLAX, etc.). Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy or for children with constipation. Macrogol (with brand names such as Laxido, Movicol and Miralax) is the generic name for polyethylene glycol used as a laxat...
Chemical uses
1. Polyethylene glycol is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluidin electronic testers. 2. PEG is frequently used to preserve waterlogged wood and other organic artifacts that have been salvaged from underwater archaeological contexts, as was the case with the warship Vasa in Stockholm, and similar cases. It replaces water in wooden objects, making the wood dimensionally stable and preventing warping or shrinking of the wood when...
Biological uses
1. An example study was done using PEG-diacrylate hydrogels to recreate vascular environments with the encapsulation of endothelial cells and macrophages. This model furthered vascular disease modeling and isolated macrophage phenotype's effect on blood vessels. 2. PEG is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions. Although polyethylene glycol is considered biologically inert, it can form non-covalent complexes with monovalent cations such...
PEG is considered biologically inert and safe by the U.S. FDA. However, a growing body of evidence shows the existence of a detectable level of anti-PEG antibodies in approximately 72% of the population, never treated with PEGylated drugs, based on plasma samples from 1990 to 1999.[further explanation needed] Due to its ubiquity in a multitude of p...
PEG, PEO, and POE refer to an oligomer or polymer of ethylene oxide. The three names are chemically synonymous, but historically PEG is preferred in the biomedical field, whereas PEO is more prevalent in the field of polymer chemistry. Because different applications require different polymer chain lengths, PEG has tended to refer to oligomers and p...
The production of polyethylene glycol was first reported in 1859. Both A. V. Lourenço and Charles Adolphe Wurtz independently isolated products that were polyethylene glycols. Polyethylene glycol is produced by the interaction of ethylene oxide with water, ethylene glycol, or ethylene glycol oligomers. The reaction is catalyzed by acidic or basic c...
PEO's have "very low singledose oral toxicity", on the order of tens of grams per kg body weight (oral). Because of its low toxicity, PEO is used in a variety of edible products.The polymer is used as a lubricating coating for various surfaces in aqueous and non-aqueous environments. The precursor to PEGs is ethylene oxide, which is hazardous. Ethy...
Budget. $6.83 billion (2024–25) Website. who.int. The World Health Organization ( WHO) is a specialized agency of the United Nations responsible for international public health. [2] It is headquartered in Geneva, Switzerland, and has six regional offices [3] and 150 field offices worldwide. [4] The WHO was established on April 7, 1948, and ...
Signed into law by President Bill Clinton on August 21, 1996. The Health Insurance Portability and Accountability Act of 1996 ( HIPAA or the Kennedy – Kassebaum Act [1] [2]) is a United States Act of Congress enacted by the 104th United States Congress and signed into law by President Bill Clinton on August 21, 1996. [3]
Spam (stylized as SPAM) is a brand of processed canned pork and ham made by Hormel Foods Corporation. It was introduced in 1937 and gained popularity worldwide after its use during World War II. [1] By 2003, Spam was sold in 41 countries (and trademarked in over 100) on six continents. [2]
