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Potassium-sparing diuretics or antikaliuretics [1] refer to drugs that cause diuresis without causing potassium loss in the urine. [2] They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. [3]
Potassium-sparing diuretics These are diuretics which do not promote the secretion of potassium into the urine; thus, potassium is retained and not lost as much as with other diuretics. [ citation needed ] The term "potassium-sparing" refers to an effect rather than a mechanism or location; nonetheless, the term almost always refers ...
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Finerenone blocks mineralocorticoid receptors, which makes it a potassium-sparing diuretic. This table compares inhibitory (blocking) concentrations (IC 50, unit: nM) of three antimineralocorticoids.
- BAY 94-8862
- Kerendia
- AU: D
- Oral
Hypokalemia which is recurrent or resistant to treatment may be amenable to a potassium-sparing diuretic, such as amiloride, triamterene, spironolactone, or eplerenone. Concomitant hypomagnesemia will inhibit potassium replacement, as magnesium is a cofactor for potassium uptake.
- Blood potassium < 3.5 mmol/L
- Cardiac arrest
- Dietary changes, potassium supplements, based on the underlying cause
Amiloride, sold under the trade name Midamor among others, is a medication typically used with other medications to treat high blood pressure or swelling due to heart failure or cirrhosis of the liver. [1] [2] Amiloride is classified as a potassium-sparing diuretic.
- C₆H₈ClN₇O
- Midamor, others
- Nil
- By mouth
Furosemide is a type of loop diuretic that works by decreasing the reabsorption of sodium by the kidneys. [4] . Common side effects of furosemide injection include hypokalemia (low potassium level), hypotension (low blood pressure), and dizziness. [5] Furosemide was patented in 1959 and approved for medical use in 1964. [6] .
Loop diuretics are pharmacological agents that primarily inhibit the Na-K-Cl cotransporter located on the luminal membrane of cells along the thick ascending limb of the loop of Henle. [4] . They are often used for the treatment of hypertension and edema secondary to congestive heart failure, liver cirrhosis, or chronic kidney disease.
