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蛋白質S缺乏症是因PROS1基因（3q11.1）變異所導致，PROS1基因製造血液中控制血液凝結的蛋白質S（Protein S），蛋白質S可幫助阻斷（去活性；inactivate）促進形成血液凝固的特定蛋白。
2019年3月28日 · Protein S 是一種維他命K依存血漿醣蛋白，可以協助Protein C抑制凝固因子Va及VIIIa，調節凝固系統。 Protein S以兩種形態存在，一種是具有活性的自由形態，一種是不具活性與蛋白質結合在一起。
蛋白S（proteinS，PS）是一種維生素K依賴性酶原，可協同活化蛋白C（APC），消除凝血因子Xα對凝血因子Vα、凝血因子Ⅸα對凝血因子Ⅷα的保護作用，使之被水解。. PS、蛋白C、蛋白C抑制物和血栓調節蛋白共同組成機體內重要的抗凝系統——蛋白C抗凝系統，在 ...
2021年9月9日 · Protein S (PS) is an essential natural anticoagulant. PS deficiency is a major contributor to acquired hypercoagulability. Acquired hypercoagulability causes myocardial infarction, stroke, and deep vein thrombosis in millions of individuals. Yet, despite its importance in hemostasis, PS is the least understood anticoagulant.
Protein S (also known as PROS) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein .
2024年3月5日 · Protein S deficiency is an inherited thrombophilia associated with an increased risk of thromboembolism. Establishing a diagnosis of hereditary protein S deficiency may be difficult, particularly in the setting of an acute thrombosis or anticoagulant administration. This topic review discusses the diagnosis and management of protein S deficiency.
2022年12月5日 · Protein S deficiency is classified into 3 phenotypes based on free and total protein S antigen and functional protein S activity by the International Society on Thrombosis and Hemostasis (ISTH), as discussed in the etiology section.
2023年4月23日 · Protein C and protein S are glycoproteins, predominantly synthesized in the liver, that are important components of the natural anticoagulant system in the body. [1] [2] They are Vitamin K dependent and serve as essential components in maintaining physiologic hemostasis.
蛋白S是一种维生素K–依赖性蛋白，是活化蛋白C–介导的Va和VIIIa因子降解的辅因子。 因此，蛋白S和蛋白C是天然血浆抗凝系统的组成部分。 血浆蛋白S的杂合缺失易诱发静脉血栓形成。 杂合蛋白S缺乏在遗传、发生率、实验室检查、治疗和预防方面与杂合蛋白C缺乏是类似的。 纯合蛋白S缺乏可引起新生儿暴发性紫癜，与纯合蛋白C引起的新生儿暴发性紫癜在临床上很难鉴别。 获得性蛋白质 C（以及随后不久的蛋白质 S）缺乏症发生在患有以下疾病的患者中： 弥散性血管内凝血 (DIC)、肝脏疾病、维生素 K 缺乏以及接受华法林治疗的患者。 当患者使用 雌激素 替代疗法或避孕，以及怀孕期间由于 雌激素 对游离蛋白S水平的影响，也可能出现蛋白S缺乏症。 炎症也会影响游离蛋白S的水平。
2022年8月1日 · Background: Protein S is a central regulator of coagulation as it critically participates in down-regulation of both extrinsic and intrinsic pathways of the coagulation cascade. In this review, we aim to provide an update on protein S and its anticoagulant
