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DEHP is readily absorbed and distributed in the body, but there is no evidence of accumulation. The metabolism of DEHP involves several pathways and yields a variety of metabolites. The major step in the metabolism of DEHP is hydrolysis by lipases to MEHP (mono(2-ethylhexyl)phthalate) and 2-ethylhexanol.
2023年11月28日 · Phthalates form a family of synthetic chemicals with a wide variety of uses, ranging from consumer to industrial products. There are different kind of phthalates and they are commonly used as softeners to make plastics, such as PVC, more flexible and durable. Due to their wide use, phthalates can be found almost everywhere in our environment.
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DEHP does not hydrolyse in water. The biodegradation of DEHP is varying in available studies. Based on the results of standard biodegradation test DEHP is readily biodegradable. Experimental data indicates a biodegradation halflife for DEHP in surface water of 50 days, and 300 days in aerobic sediment.
EC Name: Bis (2-ethylhexyl) phthalate. CAS Number: 117-81-7. Molecular formula: C24H38O4. IUPAC Name: 1,2-bis (2-ethylhexyl) benzene-1,2-dicarboxylate.
applications DEHP has also been used in adhesives, sealants (which are often applied to windows and doors for improved insulation), rubber, lacquers, paints and printing inks. Therefore, DEHP can be found in building and construction materials (e.g. in
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Generally, DEHP is rapidly absorbed from the gastrointestinal tract following oral administration. The extent of absorption in rats is around 50% for doses up to about 200 mg/kg bw. At higher doses, it appears that absorption in non-human primates is dose-limited in contrast to rodents.
