搜尋結果
纖溶酶（英語： Plasmin，EC 3.4.21.7），或譯為血漿酶、胞漿素。 是 血漿 中的一種重要 酶 用以降解許多 血漿蛋白 ，包括 纖維蛋白 凝塊 。 纖維蛋白的降解被稱為 纖溶作用 （ 英語 ： fibrinolysis ） 。
Plasmin is a serine protease that acts to dissolve fibrin blood clots. Apart from fibrinolysis, plasmin proteolyses proteins in various other systems: It activates collagenases, some mediators of the complement system, and weakens the wall of the Graafian follicle
人類有種罕見疾病稱為 第一型纖溶酶原缺損症 （英语：plasminogen deficiency type I） （OMIM 217090），即是因PLG基因變異，患者常會發生 木樣結膜炎 （英语：ligneous conjunctivitis）。 交互作用. 纖溶酶能與 Thrombospondin 1 （英语：Thrombospondin 1）[3][4] 、 Alpha 2-antiplasmin （英语：Alpha 2-antiplasmin）[5][6]，和 IGFBP3 （英语：IGFBP3）[7] 進行 交互作用。 参考文献. ^ Entrez Gene: plasminogen. （原始内容 存档 于2019-09-13）.
Plasmin is generated from the zymogen plasminogen on the surface of the fibrin clot, or on cell surfaces, by either tissue plasminogen activator (tPA) or urokinase (uPA) [5]. Proteolysis of fibrin gives rise to soluble fibrin degradation products (FDPs), some of which have immunomodulatory and chemotactic functions.
2022年9月26日 · Plasminogen activation results in increased conversion of plasminogen to plasmin, the latter an enzyme that breaks down the fibrinogen in blood clots. There is a wide usage of tissue plasminogen activators in clinical practice during treating ischemic cerebral
- Jonathan M. Katz, Prasanna Tadi
- 2022/09/26
- 2019
其他人也問了
What is the role of plasminogen in fibrinolysis?
What happens when a plasminogen is bound to fibrin?
How does fibrin activate a plasminogen?
Is plasminogen a fibrinolytic protease?
What does plasmin do?
What enzyme degrades fibrin clots?
Plasminogen, primarily a blood protein involved in fibrinolysis, also participates in inflammatory processes throughout the body. Baker and Strickland summarize the role of plasminogen and its activator system in regulating inflammation in health and disease.
2021年5月27日 · Plasmin, the proteolytically active form of plasminogen, is known for its essential role in fibrinolysis. To date, therapeutic targeting of the fibrinolytic system has been for 2 purposes: to promote plasmin generation for thromboembolic conditions or to stop plasmin to reduce bleeding.
