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2023年10月18日 · This topic review discusses the diagnosis and management of protein C deficiency (inherited and acquired). Separate topic reviews address the appropriate use of thrombophilia testing in various clinical settings:
蛋白C缺乏症 (Protein C deficiency)是 體染色體顯性遺傳 所致的栓塞性疾病 (thrombotic disease)，在白種人的盛行率約0.2～0.5%。 Protein C是一種醣蛋白，在肝臟合成，具有抗凝功能，依賴於維生素K (Protein C is vitamin K-dependent)。 當 Protein C異常，易導致靜脈血栓形成 (Protein C deficiency is associated with an increased incidence of venous thromboembolism)。 (分類) 蛋白C缺乏症原因可區分為二類：
- What Are The Signs and Symptoms of Protein C Deficiency?
- What Causes Protein C Deficiency?
- Are All Forms of Protein C Deficiency Inherited?
If you have the mild form of protein C deficiency, you’re at risk for: 1. Blood clots in your veins (also called venous thromboembolism). Blood clots usually form in your legs (deep vein thrombosis) but can also form in the veins of the large and small intestines, your brain, the main vein to your liver and in other areas. You may not have symptoms...
Protein C deficiency can be caused by a mutation in a gene called PROC. The PROC gene provides the instructions for making protein C. People with the mild form of protein C deficiency have either low levels of protein C (Type I) or have a normal level but a protein C that doesn’t function normally (Type II). A child of a couple in which one parent ...
Protein C deficiency can also develop under certain conditions: 1. Vitamin K deficiency. 2. Warfarin therapy. 3. Severe liver disease. 4. Disseminated intravascular coagulation (DIC). 5. Severe bacterial infection (sepsis).
2021年6月23日 · 蛋白質C缺乏症（Protein C deficiency）是一種會讓血液異常凝結風險增加的疾病，其致病原因為PROC基因變異使得製造蛋白質C的功能受影響而導致。 蛋白質C是肝臟生合成的醣蛋白，具有抗凝血的功能，在人體血液中循環時，為不具活性的酶原（zymogen）。
Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease. It was first described in 1981. [2] . The disease belongs to a group of genetic disorders known as thrombophilias.
2023年7月4日 · Protein C deficiency is a rare disorder, characterized by a reduction in the activity of protein C, a plasma serine protease involved in the regulation of blood coagulation. The active form of protein C, activated protein C (APC), exerts potent anticoagulant activity.
Protein C is a vitamin K–dependent protein, as are coagulation factors II (prothrombin), VII, IX, and X and proteins S and Z. Because activated protein C (APC) degrades factors Va and VIIIa, APC is a natural plasma anticoagulant. Decreased protein C due to a genetic or an acquired abnormality predisposes to venous thrombosis (1).
