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Activated protein C resistance occurs when APC is unable to perform its functions. This disease has similar symptoms to protein C deficiency. The most common mutation leading to activated protein C resistance among Caucasians is at the cleavage site in 506
Activated Protein C is a protein that plays a crucial role in reducing blood clot formation and inflammation. It achieves this by inhibiting the production of thrombin, a pro-inflammatory and pro-coagulant factor, and by reducing the production of certain inflammatory molecules.
2009年12月31日 · Protein C is a soluble, vitamin K–dependent, plasma serine protease that plays a central role in endogenous anticoagulation. 22 The activated form is generated when thrombin, bound to the cofactor...
- Susanne Toussaint, Herwig Gerlach
- 2009
2020年7月6日 · Activated protein C inactivates cofactors Va and VIIIa with the assistance of protein S, down regulates the amplification and progression of the coagulation cascade and maintains patency of the...
- Bosko M. Stojanovski, Leslie A. Pelc, Enrico Di Cera
- 2020
Activated protein C (APC), an endogenous protein that promotes fibrinolysis and inhibits thrombosis and inflammation, is an important modulator of the coagulation and inflammation associated with severe sepsis. During sepsis, reduced levels of APC are associated with rising risk of death.
2001年3月7日 · Several properties of Activated Protein C, including its unique positioning to regulate coagulopathies in the microvasculature and the ability of EPCR to facilitate Protein C activation, support the continued development of Activated Protein C-mediated strategies
2023年4月23日 · Protein C is activated by the thrombin-thrombomodulin complex to form activated protein C (APC) on the surface of the vascular endothelial cells. Once protein C is activated, free protein S in the plasma is a cofactor, along with phospholipids and calcium, to inactivate factor V and factor VIIIa at specific polypeptide arginine ...
activated protein c 相關
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