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Menadione sodium bisulfite is a water-soluble form of menadione, which belongs to the Vitamin K class of compounds. These are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione is a prothrombogenic compound and is used as a model quinone in cell culture and in vivo investigations.
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Menadione sodium sulfonate is an organic sodium salt that is the monosodium salt of menadione sulfonate. A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted into active vitamin K2, menaquinone, after alkylation in vivo. It contains a menadione sulfonate.
Menadione（menadione sodium bisulfite、vit k3）的藥理作用. 本品可生成具活性的維他命K，可調節凝血蛋白的合成、促進凝血反應。. Menadione（menadione sodium bisulfite、vit k3）的副作用. Menadione（menadione sodium bisulfite、vit k3）的副作用. 噁心、嘔吐、溶血性貧血。. 服用Menadione ...
甲萘醌 （英語： Menadione， 2-甲基-1,4-萘醌，有時也稱作 維生素K3） [2] 是一種 化學式 為C 6 H 4 (CO) 2 C 2 H (CH 3)的有機化合物。 此物在體內可由 NQO1 和 UBIAD1 轉化為 維生素K （K2, MK-4）， [3] 但過量使用會導致 活性氧類 產生。 [4] K3一般是合成產生，用作動物飼料和低收入地區的人類營養補充劑。 根據 歐洲食品安全局 的報告，K3用於動物飼料時從未導致過毒性產生。 [5] 口服天然形式的維生素K1、K2也會在體內生成K3。 [2] K3可以穿透血腦屏障。 [3] 參考文獻. [編輯] ^ The Merck Index, 11th Edition, 5714.
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Generic Name
1. Menadione
DrugBank Accession Number
1. DB00170
Background
1. A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
Indication
1. The primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.Reduce drug development failure ratesBuild, train, & validate machine-learning models with evidence-based and structured datasets.See howsee_moreBuild, train, & validate predictive machine-learning models with structured datasets.See how
Associated Conditions
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Contraindications & Blackbox Warnings
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Drug Interactions information
1. This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Food Interactions
1. Not Available
Drug product information from 10+ global regionsOur datasets provide approved product information including: dosage, form, labeller, route of administration, and marketing period.Access nowsee_more...SynkaviteUNII
1. 723JX6CXY5
CAS number
1. 58-27-5
InChI Key
1. MJVAVZPDRWSRRC-UHFFFAOYSA-N
Synthesis Reference
1. Joachim U. Schneider, Hans Kiefer, "Menadione choline bisulfite adduct, its preparation and antihemorrhagic compositions." U.S. Patent US4735969, issued January, 1980.US4735969
General References
1. Not Available
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How is menadione converted to vitamin K 2?
Menadione is a synthetic [3] [4] organic compound with the formula C 6 H 4 (CO) 2 C 2 H(CH 3). It is an analog of 1,4-naphthoquinone with a methyl group in the 2-position. [ 5 ] It is sometimes called vitamin K 3 .
Menadione bisulfite is a water-soluble analog of Vitamin K3. Pharmacologic studies on menadione bisulfate indicad that its toxicity is relatively low. In man, doses approximately ten times as great as those generally recommended for therapeutic use, given daily for a period of one week.
