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   What causes thiamine deficiency?

   • Up to 80% of people with an addiction to alcohol develop thiamine deficiency. 1 Heavy alcohol use causes inflammation of the stomach lining and digestive tract, which reduces the body’s ability to absorb vitamins. Poor dietary choices and a lack of nutrition also rob the body of essential vitamins. 4 Thiamine deficiency can cause:

   Alcohol and thiamine - The Alcohol and Drug Foundation

   adf.org.au/insights/alcohol-related-thiamine-deficiency/

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   How common is thiamine deficiency?

   • Thiamine deficiency, although rare in most developed countries, is common in people who drink excessive amounts of alcohol. Up to 80% of people with an addiction to alcohol develop thiamine deficiency. 1 Heavy alcohol use causes inflammation of the stomach lining and digestive tract, which reduces the body’s ability to absorb vitamins.

   Alcohol and thiamine - The Alcohol and Drug Foundation

   adf.org.au/insights/alcohol-related-thiamine-deficiency/

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   How can thiamine deficiency be treated?

   • Thiamine deficiency can be treated by stopping alcohol consumption, eating a nutritious diet and by taking vitamin B1 supplements. 1 However, diet and supplements alone are not effective if heavy alcohol use continues because alcohol will block absorption.

   Alcohol and thiamine - The Alcohol and Drug Foundation

   adf.org.au/insights/alcohol-related-thiamine-deficiency/

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   How does ethanol affect thiamine absorption?

   • In addition, the consumption of ethanol compromises the absorption of thiamine, contributing to reduced thiamine levels in the CNS, one of the factors linked to MBD. Thiamine deficiency, also generated by low intake or absorption disorders, impairs thiamine pyrophosphate-dependent enzyme activity.

   Thiamine deficiency, oxidative metabolic pathways and ethanol-induced

   www.nature.com/articles/ejcn2016267

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   Can thiamine (vitamin B1) deficiency cause brain damage?

   • Harper, C. Thiamine (vitamin B1) deficiency and associated brain damage is still common throughout the world and prevention is simple and safe! Eur. J.

   Clinical and pathological features of alcohol-related brain damage

   www.nature.com/articles/nrneurol.2011.42

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   Why is thiamine important?

   • Thiamine, also known as vitamin B1, is an essential nutrient used by the body to convert food into energy. Thiamine takes the fats, proteins and carbohydrates we consume and uses them to fuel functions of the heart, nerves and brain. 1 Because the body cannot produce thiamine, it must be consumed through foods like:

   Alcohol and thiamine - The Alcohol and Drug Foundation

   adf.org.au/insights/alcohol-related-thiamine-deficiency/

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2. www.vghtc.gov.tw › UnitPage › RowViewDetail(認識酒精戒斷症候群 ) 臺中榮總全球資訊網 Taichung Veterans ...

   www.vghtc.gov.tw › UnitPage › RowViewDetail

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   2024年3月21日 · 維他命B1（thiamine）為體內細胞代謝醣類的必需營養物質，其在體內無法被合成，只能靠體外攝入。 因個案長期飲酒多合併營養不良，故常有thiamine缺乏的情形。

3. adf.org.au › insights › alcohol-related-thiamine-deficiencyAlcohol related thiamine deficiency - Alcohol and Drug Foundation

   adf.org.au › insights › alcohol-related-thiamine-deficiency

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   • Beriberi
   • Wernicke–Korsakoff’S Syndrome
   • Treating Thiamine Deficiency

   There are two types of beriberi - wet beriberi and dry beriberi.6 Wet beriberi affects the heart and circulatory system and in extreme cases can cause heart failure.6 Dry beriberi damages the nerves and can lead to decreased muscle strength and eventually, muscle paralysis.6

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   Wernicke-Korsakoff’s syndrome most commonly occurs in alcohol-dependent people. This nerve and brain disease is made up of two conditions/phases – Wernicke encephalopathy, which occurs first and then progresses to Korsakoff’s syndrome.1 Wernicke’s encephalopathy is life threatening. Symptoms include: 1. confusion 2. loss of memory activity 3. loss ...

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   Thiamine deficiency can be treated by stopping alcohol consumption, eating a nutritious diet and by taking vitamin B1 supplements.1 However, diet and supplements alone are not effective if heavy alcohol use continues because alcohol will block absorption. If you’re concerned about vitamin depletion as a result of drinking alcohol, talk to your heal...

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4. 影片

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     10:06

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     Thiamine (Vit B1) Deficiency Signs & Symptoms (& Why They Occur)

     2021年9月30日

     觀看次數：47.2萬

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     9:42

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     ALCOHOL & WERNICKE-KORSAKOFF SYNDROME | BRAIN DISORDER caused by Thiamine (Vitamin B1) Deficiency |

     2022年6月22日

     觀看次數：3.9萬

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     2:02

     youtube.com

     2-Minute Neuroscience: Wernicke-Korsakoff Syndrome

     2020年8月5日

     觀看次數：15.4萬

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5. my.clevelandclinic.org › health › diseasesWernicke-Korsakoff Syndrome: Causes, Symptoms & ...

   my.clevelandclinic.org › health › diseases

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   2022年4月4日 · Wernicke-Korsakoff syndrome is an unusual type of memory disorder due to a lack of thiamin (vitamin B1) requiring immediate treatment. It most often happens in people with alcohol use disorder and malnutrition. While there isn’t a cure, healthcare providers can recommend treatments to manage your symptoms.

6. pubmed.ncbi.nlm.nih.gov › 27818067[Thiamine (vitamin B1) treatment in patients with alcohol ...

   pubmed.ncbi.nlm.nih.gov › 27818067

   In patients at high risk of thiamine deficiency, parenteral thiamine 250-500mg/day should be given for 3-5 days, followed by oral thiamine 250-300mg/day. In patients at low risk (with uncomplicated alcohol dependence), oral thiamine 250-500mg/day should be

   • 作者: Alain Dervaux, Xavier Laqueille

   • Publish Year: 2017

7. www.nature.com › articles › nrneurolClinical and pathological features of alcohol-related brain ...

   www.nature.com › articles › nrneurol

   2011年4月12日 · WE is an acute, potentially reversible neurological disorder caused by a deficiency in or severe depletion of thiamine (vitamin B 1) that can result from chronic alcoholism, poor nutrition,...

   • 作者: Natalie M. Zahr, Kimberley L. Kaufman, Clive G. Harper

   • Publish Year: 2011

8. 圖片

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9. www.nature.com › articles › ejcn2016267Thiamine deficiency, oxidative metabolic pathways and ...

   www.nature.com › articles › ejcn2016267

   2017年2月22日 · Vitamin deficiencies, mainly vitamin B1, and malnourishment are common characteristics in chronic alcoholics that may lead to MBD, due to liver damage-induced metabolic disturbance ultimately...

10. pmc.ncbi.nlm.nih.gov › articles › PMC2904165Unraveling the pathophysiology of alcohol-induced thiamin ...

    pmc.ncbi.nlm.nih.gov › articles › PMC2904165

    In alcoholic subjects, changes in thiamin supply combined with impaired epithelial thiamin transport and increased metabolic demand are likely the major factors contributing to alcohol-related brain damage.