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Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, also known as angiotensin receptor blockers, angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and (AT
The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure.
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What are angiotensin receptor blockers (ARBs)?
What are angiotensin II receptor antagonists?
What are angiotensin II receptors?
How does angiotensin II (AII) work?
The angiotensin II receptors, (ATR1) and (ATR2), are a class of G protein-coupled receptors with angiotensin II as their ligands. [1] They are important in the renin–angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. [2]
The action of AII itself is targeted by angiotensin II receptor antagonists, which directly block angiotensin II AT 1 receptors. Angiotensin II is degraded to angiotensin III by angiotensinases located in red blood cells and the vascular beds of most tissues.
- angiotensin
Telmisartan is an angiotensin II receptor blocker that shows high affinity for the angiotensin II receptor type 1 (AT 1), with a binding affinity 3000 times greater for AT 1 than AT 2. In addition to blocking the renin–angiotensin system , telmisartan acts as a selective modulator of peroxisome proliferator-activated receptor gamma ...
- C₃₃H₃₀N₄O₂
- Micardis, Actavis, others
- AU: D
- Minimal liver (glucuronidation)
Angiotensin-converting enzyme 2 ( ACE2) [5] is an enzyme that can be found either attached to the membrane of cells (mACE2) in the intestines, kidney, testis, gallbladder, and heart or in a soluble form (sACE2).
Mechanism of action. Pharmacokinetics. History. References. Further reading. External links. Losartan, sold under the brand name Cozaar among others, is a medication used to treat high blood pressure (hypertension). [4] . It is in the angiotensin receptor blocker (ARB) family of medication, and is considered protective of the kidneys.
