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In particular, the ability to synthesize vitamin C is presumed to have been lost and then later re-acquired in at least two cases. The ability to synthesize vitamin C has also been lost in about 96% of extant fish (the teleosts).
- C₆H₈O₆
- Ascor, Cecon, Cevalin, others
Scurvy, including subclinical scurvy, is caused by a deficiency of dietary vitamin C, since humans are unable to metabolically synthesize vitamin C. Provided the diet contains sufficient vitamin C, the lack of working L-gulonolactone oxidase (GULO) enzyme has
- Based on symptoms
- Lack of vitamin C
- Weakness, feeling tired, changes to hair, sore arms and legs, gum disease, easy bleeding
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The loss of this enzyme activity is responsible for the inability of guinea pigs to enzymatically synthesize vitamin C. Both these events happened independently of the loss in the haplorrhine suborder of primates, which includes humans.
- GULOP, GULO, SCURVY, gulonolactone (L-) oxidase, pseudogene
Auxotrophy ( Ancient Greek: αὐξάνω "to increase"; τροφή "nourishment") is the inability of an organism to synthesize a particular organic compound required for its growth (as defined by IUPAC ). An auxotroph is an organism that displays this characteristic; auxotrophic is the corresponding adjective. Auxotrophy is the opposite of ...
Deficiency of vitamin C causes scurvy, formerly a major disease of sailors in long sea voyages. It is used as a food additive and a dietary supplement for its antioxidant properties. The "d" form can be made via chemical synthesis, but has no significant biological
- C₆H₈O₆
- 176.124 g·mol−1
- 190 to 192 °C (374 to 378 °F; 463 to 465 K) decomposes
- 330 g/L
University of Pittsburgh, Columbia University. Charles Glen King (October 22, 1896 – January 23, 1988) was an American biochemist who was a pioneer in the field of nutrition research and who isolated vitamin C at the same time as Albert Szent-Györgyi. [1] A biography of King states that many feel he deserves equal credit with Szent-Györgyi ...
Metabolism (/ m ə ˈ t æ b ə l ɪ z ə m /, from Greek: μεταβολή metabolē, "change") is the set of life-sustaining chemical reactions in organisms.The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks of proteins, lipids, nucleic acids, and some carbohydrates; and the ...
