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  1. COVID-19 - Wikipedia

    en.wikipedia.org › wiki › Covid-19

    t. e. Coronavirus disease 2019 ( COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease has since spread ...

  2. Turkey - Wikipedia

    en.wikipedia.org › wiki › Turkey

    Turkey is a regional power, and a newly industrialized and developing country, with a geopolitically strategic location. Its economy, which is classified among the emerging and growth-leading economies, is the twentieth-largest in the world by ...

  3. Hughes H-4 Hercules - Wikipedia

    en.wikipedia.org › wiki › Hughes_H-4_Hercules
    • Design and Development
    • Operational History
    • Display
    • Specifications
    • See Also
    • References
    • External Links

    In 1942, the U.S. War Department needed to transport war materiel and personnel to Britain. Allied shipping in the Atlantic Ocean was suffering heavy losses to German U-boats, so a requirement was issued for an aircraft that could cross the Atlantic with a large payload. Wartime priorities meant the aircraft could not be made of strategic materials (e.g., aluminum). The aircraft was the brainchild of Henry J. Kaiser, a leading Liberty ship builder and manufacturer. Kaiser teamed with aircraft designer Howard Hughes to create what would become the largest aircraft yet built. It was designed to carry 150,000 pounds (68,000 kg), 750 fully equipped troops or two 30-ton M4 Sherman tanks.The original designation "HK-1" reflected the Hughes and Kaiser collaboration. The HK-1 aircraft contract was issued in 1942 as a development contract and called for three aircraft to be constructed in two years for the war effort. Seven configurations were considered, including twin-hull and single-hull...

    Hughes returned to California during a break in the Senate hearings to run taxi tests on the H-4.On November 2, 1947, the taxi tests began with Hughes at the controls. His crew included Dave Grant as copilot, two flight engineers, Don Smith and Joe Petrali, 16 mechanics, and two other flight crew. The H-4 also carried seven invited guests from the press corps and an additional seven industry representatives. In total, thirty-six people were on board. Four reporters left to file stories after the first two taxi runs while the remaining press stayed for the final test run of the day. After picking up speed on the channel facing Cabrillo Beach, the Hercules lifted off, remaining airborne for 26 seconds at 70 ft (21 m) off the water at a speed of 135 miles per hour (217 km/h) for about one mile (1.6 km). At this altitude, the aircraft still experienced ground effect.Nevertheless, the brief flight proved to detractors that Hughes' (now unneeded) masterpiece was flight-worthy—thus vindica...

    Ownership of the H-4 was disputed by the U.S. government, which had contracted for its construction. In the mid-1970s, an agreement was reached whereby the Smithsonian Institution's National Air and Space Museum would receive the Hughes H-1 Racer and section of the H-4's wing, the Summa Corporationwould pay $700,000 and receive ownership of the H-4, the U.S. government would cede any rights, and the aircraft would be protected "from commercial exploitation." In 1980, the H-4 was acquired by the Aero Club of Southern California, which later put the aircraft on display in a very large geodesic dome next to the Queen Mary ship exhibit in Long Beach, California. The large dome facility became known as the Spruce Goose Dome. The very large enclosed indoor dome area around the H-4 consisted of meeting and special event space, elaborate audio-visual displays about Howard Hughes and the aircraft itself, and dining areas for tourists. Many convention groups held large dinners, sales meetings...

    Performance specifications are projected. General characteristics 1. Crew:3 2. Length:218 ft 8 in (66.65 m) 3. Wingspan:320 ft 11 in (97.82 m) 4. Height:79 ft 4 in (24.18 m) 5. Fuselage height:30 ft (9.1 m) 6. Empty weight:250,000 lb (113,398 kg) 7. Powerplant: 8 × Pratt & Whitney R-4360 Wasp Major28-cylinder air-cooled radial piston engines, 3,000 hp (2,200 kW) each 8. Propellers: 4-bladed Hamilton Standard, 17 ft 2 in (5.23 m) diameter constant-speed propellers Performance 1. Cruise speed:250 mph (400 km/h, 220 kn) 2. Range:3,000 mi (4,800 km, 2,600 nmi) 3. Service ceiling:20,900 ft (6,400 m)

    Bibliography

    1. Francillon, René J. McDonnell Douglas Aircraft since 1920: Volume II. Annapolis, Maryland: Naval Institute Press, 1990. ISBN 1-55750-550-0. 2. McDonald, John J. Howard Hughes and the Spruce Goose. Blue Ridge Summit, Pennsylvania: Tab Books Inc., 1981. ISBN 0-8306-2320-5. 3. Odekirk, Glenn E. Spruce Goose (Title inside cover: HK-1 Hercules: A Pictorial History of the Fantastic Hughes Flying Boat). Long Beach, California: Glenn E. Odekirk and Frank Alcantr, Inc., 1982. No ISBN. 4. Parker, Da...

    Evergreen Aviation & Space Museum, home of the Spruce Goose
    Vintage photos of Spruce Goose's construction
  4. Emergency Use Authorization - Wikipedia

    en.wikipedia.org › wiki › Emergency_Use_Authorization
    • Use
    • History of Legal Authority For EUAs
    • Applicability and The Animal Efficacy Rule
    • Use During Pandemics
    • See Also

    A review article by Rizk et al provides a summary of the US experience in 2020 with pharmacological EUA approvals during the COVID-19 pandemic.It also provides a description of, and clinical rationale for, the EUA-approved drugs during the pandemic and concluding reflections on the EUA program and its potential future uses. After initial authorizations for serious diseases such as pandemic influenza and emerging diseases, EUAs were also authorized for medical countermeasures (MCMs) principally in response to public health emergencies such as bioterrorism, including chemical, biological, radiological and nuclear (CBRN) threats. Subsequent legislative authorities expanded the latitude of the class of drugs eligible for consideration, and the range of testing to which the drug or therapy has been subjected. The scope and applicability of EUAs is also affected by presidential executive orders (Title 3 of the Code of Federal Regulations), which may affect the definition of the situations...

    In the United States, EUAs are authorized by Section 564 of the Federal Food Drug and Cosmetic Act (FDCA) of 1938 (Public Law 75-717) as added and subsequently amended by the Project BioShield Act of 2004 (S. 15, Public Law 108-276) for funding of the development and procurement of medical countermeasures against CBRN threats, the Pandemic and All-Hazards Preparedness Reauthorization Act of 2013 (H.R. 307, Pub.L. 113–5 (text) (pdf)), the 21st Century Cures Act of 2016 (H.R. 34, Public Law 114-255) and Pub.L. 115–92 (text) (pdf)of 2017 (no short title).

    EUAs may be applied to drugs, devices or biological product. EUAs may either permit the emergency use of an unapproved drug, device or biologic product, or permit an unapproved use of an approved drug, device or biologic product. Furthermore, drugs, devices or biologic productsmay or may not have undergone human efficacy trials, due to risk, feasibility or ethical considerations. Drugs, devices or biologic products which have only been tested or approved under the animal efficacy rule are loosely known as animal products. Under certain conditions, an EUA may authorize the emergency use in humans, of drugs, devices or biologic products approved under the animal efficacy rule. EUAs may also only be implemented during the period of a public health emergency as defined by a declaration of the Secretary of Health and Human Services (HHS). Conditions determining the applicability of suchdeclarations may be specified by federal statute. Code of Federal Regulations or an presidential execut...

    In response to requests from the U.S. Centers for Disease Control and Prevention (CDC), on April 27, 2009, the FDA issued Emergency Use Authorizations to make available diagnostic and therapeutic tools to identify and respond to the 2009 swine flu pandemic under certain circumstances. The agency issued these EUAs for the use of certain powerful antiviral drugs, and for the quantitative PCR swine flu test. On February 4, 2020, the Secretary of HHS declared the public health emergency for the novel SARS-CoV-2 virus, which causes the disease COVID-19, for deployment of the FDA EUA for certain medical devices involved in the diagnosis of COVID-19. In February 2020, The FDA issued an EUA for COVID-19 testing CDC test kits for COVID-19. In 2020, the FDA issued EUAs for remdesivir, convalescent plasma, Fresenius Propoven 2% emulsion (propofol), hydroxychloroquine (revoked, although its license for established indications remains), and bamlanivimab – all in response to the COVID-19 pandemic...

  5. Microsoft Edge - Wikipedia

    en.wikipedia.org › wiki › Microsoft_Edge
    • Features
    • Development
    • Performance
    • Reception
    • Further Reading
    • External Links

    Microsoft Edge is the default web browser on Windows 10, Windows 10 Mobile, Windows 11, Xbox One, and Xbox Series X and Series S consoles, replacing Internet Explorer 11 and Internet Explorer Mobile. As its development and release is dependent on the model of Windows as a service, it is not included in Windows 10 Enterprise Long-Term Servicing Channel (LTSC) builds. Microsoft initially announced that Edge would support the legacy Trident(MSHTML) layout engine for backwards compatibility, but later said that, due to "strong feedback," Edge would use a new engine, while Internet Explorer would continue to provide the legacy engine. Favorites, reading list, browsing history and downloads are viewed at the Hub, a sidebarproviding functionality similar to Internet Explorer's Downloads manager and Favorites Center. Edge features a PDF reader and supports asm.js. Until January 2021, Edge also featured an integrated Adobe Flash Player (with an internal whitelist allowing Flash applets on Fa...

    Spartan

    In December 2014, writing for ZDNet, technology writer Mary Jo Foley reported that Microsoft was developing a new web browser codenamed "Spartan" for Windows 10. She said that "Spartan" would be treated as a new product separate from Internet Explorer, with Internet Explorer 11 retained alongside it for compatibility. In early January 2015, The Verge obtained further details surrounding "Spartan" from sources close to Microsoft, including reports that it would replace Internet Explorer on bot...

    Anaheim

    On December 6, 2018, Microsoft announced its intent to base Edge on the Chromium source code, using the same rendering engine as Google Chrome but with enhancements developed by Microsoft. It was also announced that there will be versions of Edge available for Windows 7, Windows 8 and macOS, plus that all versions will be updated on a more frequent basis. According to Microsoft executive Joe Belfiore, the decision for the change came after CEO Satya Nadellatold the team in 2017 that the produ...

    Early benchmarks of the EdgeHTML engine—included in the first beta release of Edge in Windows 10 Build 10049—had drastically better JavaScript performance than Trident 7 in Internet Explorer 11, with similar performance to Google Chrome 41 and Mozilla Firefox 37. In the SunSpider benchmark, Edge performed faster than other browsers, while in other benchmarks it operated slower than Google Chrome, Mozilla Firefox and Opera. Later benchmarks conducted with the version included in 10122 showed significant performance improvement compared to both IE11 and Edge back in 10049. According to Microsoft's benchmark result, this iteration of Edge performed better than both Chrome and Firefox in Google's Octane 2.0 and Apple's Jetstream benchmark. In July 2015, Edge scored 377 out of 555 points on the HTML5test. Chrome 44 and Firefox 42 scored 479 and 434 respectively, while Internet Explorer 11 scored 312. In August 2015, Microsoft released Windows 10 Build 10532 to insiders, which included Ed...

    In an August 2015 review of Windows 10 by Dan Grabham of TechRadar, Microsoft Edge was praised for its performance, despite not being in a feature-complete state at launch. Andrew Cunningham of Ars Technica praised the browser for being "tremendously promising" and "a much better browser than Internet Explorer ever was" but criticized it for its lack of functionality on launch. Thom Holwerda of OSNewscriticized Edge in August 2015 for its hidden URL bar, lack of user friendliness, poor design and a tab system that is "so utterly broken it should never have shipped in a final release". He described the browser's implemented features as "some sort of cosmic joke", saying that "infuriating doesn't even begin to describe it". Data from August 2015, a few weeks after release, showed that user uptake of Edge was low, with only 2% of overall computer users using the new browser. Among Windows 10 users usage peaked at 20% and then dropped to 14% through August 2015. In October 2015, a secur...

    Weber, Jason (January 22, 2015). "Project Spartan and the Windows 10 January Preview Build". IEBlog. Microsoft.

    Microsoft Edge Team (April 22, 2020). "Microsoft Edge and Chromium Open Source: Our Intent".
    "Microsoft Edge open source projects - demos, tools, data". GitHub.
  6. Blackpink - Wikipedia

    en.wikipedia.org › wiki › BLACKPINK

    Blackpink (Korean: 블랙핑크; commonly stylized as BLACKPINK or BLΛƆKPIИK) is a South Korean girl group formed by YG Entertainment, consisting of members Jisoo, Jennie, Rosé and Lisa.The group debuted in August 2016 with their single album Square ...

  7. Kinmen - Wikipedia

    en.wikipedia.org › wiki › Kinmen

    Kinmen, alternatively known as Quemoy, is a group of islands off the southeastern coast of mainland China, governed as a county by the Republic of China Government based on Taiwan. It lies roughly 10 km (6.2 mi) east of the city of Xiamen in ...

  8. Russia - Wikipedia

    en.wikipedia.org › wiki › Russia

    Russia (Russian: Россия, Rossiya, Russian pronunciation: [rɐˈsʲijə]), or the Russian Federation, [b] is a country spanning Eastern Europe and Northern Asia.It is the largest country in the world by area, covering over 17 million square ...

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