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According to Mosteller's "simplified calculation of body-surface area In metric terms" the body surface area = the square root of product of the weight in kg times the height in cm divided by 3600. The "normal" body surface area is generally taken to be 1.7 m2 but, in actual fact, the body surface area depends on more than just height and weight.
Medications and prescription drug information for consumers and medical health professionals. Online database of the most popular drugs and their side effects, interactions, and use. Cuts, Scrapes, Wounds, Bruises, Burns Stratagraft (Allogeneic Cultured
- Mechanism of Action
- Pharmacodynamics
- Drug Interactions
- Pharmacokinetics
- Pediatric Patients
- Effects in Hypertension
- Effects in Chronic Stable Angina
- Effects in Vasospastic Angina
- Effects in Documented Coronary Artery Disease
- Studies in Patients with Heart Failure
Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Experimental data suggest that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac ...
Following administration of therapeutic doses to patients with hypertension, NORVASC produces vasodilation resulting in a reduction of supine and standing blood pressures. These decreases in blood pressure are not accompanied by a significant change in heart rate or plasma catecholamine levels with chronic dosing. Although the acute intravenous adm...
When amlodipine and sildenafil were used in combination, each agent independently exerted its own blood pressure lowering effect [see DRUG INTERACTIONS].
After oral administration of therapeutic doses of NORVASC, absorption produces peak plasma concentrations between 6 and 12 hours. Absolute bioavailability has been estimated to be between 64 and 90%. The bioavailability of NORVASC is not altered by the presence of food. Amlodipine is extensively (about 90%) converted to inactive metabolites via hep...
Sixty-two hypertensive patients aged 6 to 17 years received doses of NORVASC between 1.25 mg and 20 mg. Weight-adjusted clearance and volume of distribution were similar to values in adults.
The antihypertensive efficacy of NORVASC has been demonstrated in a total of 15 double-blind, placebo-controlled, randomized studies involving 800 patients on NORVASC and 538 on placebo. Once daily administration produced statistically significant placebo-corrected reductions in supine and standing blood pressures at 24 hours postdose, averaging ab...
The effectiveness of 5-10 mg/day of NORVASC in exercise-induced angina has been evaluated in 8 placebo-controlled, double-blind clinical trials of up to 6 weeks duration involving 1038 patients (684 NORVASC, 354 placebo) with chronic stable angina. In 5 of the 8 studies, significant increases in exercise time (bicycle or treadmill) were seen with t...
In a double-blind, placebo-controlled clinical trial of 4 weeks duration in 50 patients, NORVASC therapy decreased attacks by approximately 4/week compared with a placebo decrease of approximately 1/week (p<0.01). Two of 23 NORVASC and 7 of 27 placebo patients discontinued from the study due to lack of clinical improvement.
In PREVENT, 825 patients with angiographically documented coronary artery disease were randomized to NORVASC (5-10 mg once daily) or placebo and followed for 3 years. Although the study did not show significance on the primary objective of change in coronary luminal diameter as assessed by quantitative coronary angiography, the data suggested a fav...
NORVASC has been compared to placebo in four 8-12 week studies of patients with NYHA Class II/III heart failure, involving a total of 697 patients. In these studies, there was no evidence of worsened heart failure based on measures of exercise tolerance, NYHA classification, symptoms, or left ventricular ejection fraction. In a long-term (follow-up...
2023年10月18日 · weight loss, stomach pain or swelling, cough, and. swollen glands in your neck, armpits, or groin. Get medical help right away, if you have any of the symptoms listed above. Common side effects of Remicade include: headache, stomach pain, nausea,
2023年1月6日 · Isuprel (isoproterenol hydrochloride) is a bronchodilator used as an inhaler to treat conditions such as asthma, bronchitis, and emphysema. In rare cases, Isuprel is given as an injection as a treatment for electrical heart block. Isuprel is available in generic form.
2022年5月4日 · The side effects of MESTINON are most commonly related to overdosage and generally are of two varieties, muscarinic and nicotinic. Among those in the former group are nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis.
2023年12月4日 · pale skin, shortness of breath, dizziness, weakness, or. tremors. Before using Adrenalin a second time, tell your doctor if your first injection caused serious side effects such as increased breathing difficulty, or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness ...
