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2022年1月24日 · Mobic User Reviews. Drug Summary. What Is Mobic? Mobic ( meloxicam) is a nonsteroidal anti-inflammatory drug ( NSAID) used to treat pain or inflammation caused by arthritis. Mobic is available in generic form. What Are Side Effects of Mobic? Common side effects of Mobic include: stomach upset, nausea, drowsiness, diarrhea, bloating, gas, dizziness,
- Mechanism of Action
- Pharmacodynamics
- Pharmacokinetics
- Specific Populations
- Drug Interactions
- Clinical Studies
- One-Year Results
- Effect on Weight Regain
- Two-Year Results
- Four-Year Results
Orlistat is a reversible inhibitor of gastrointestinal lipases. It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipases. The inactivated enzymes are thus unavailable to hydrolyze dietary fat in the form of triglycerides into a...
The dose-response relationship for orlistat in human volunteers is shown in Figure 1. The effect is the percentage of ingested fat excreted, referred to as fecal fat excretion percentage. Both individual data (open circles) and the curve predicted for the population with the maximum-effect model (continuous line) are shown in Figure 1. Figure 1 Dos...
Systemic exposure to orlistat is minimal. Following oral dosing with 360 mg 14C-orlistat, plasma radioactivity peaked at approximately 8 hours; plasma concentrations of intact orlistat were near the limits of detection (<5 ng/mL). In therapeutic studies involving monitoring of plasma samples, detection of intact orlistat in plasma was sporadicand c...
No pharmacokinetic study was conducted for specific populations such as geriatric, different races, and patients with renal and hepatic impairment.
In a multiple-dose study in 30 normal-weight subjects, coadministration of XENICAL and 40 grams of alcohol (e.g., approximately 3 glasses of wine) did not result in alteration of alcohol pharmacokinetics, orlistat pharmacodynamics (fecal fat excretion), or systemic exposure to orlistat. In a pharmacokinetic study conducted in healthy volunteers who...
The long-term effects of XENICAL on morbidity and mortality associated with obesity have not been established. The effects of XENICAL on weight loss, weight maintenance, and weight regain and on a number of comorbidities (e.g., type 2 diabetes, lipids, blood pressure) were assessed in the 4-year XENDOS study and in seven long-term (1-to 2-years dur...
Pooled data from five clinical trials indicated that the overall mean weight loss from randomization to the end of 1 year of treatment in the intent-to-treat population was 13.4 lbs in the patients treated with XENICAL and 5.8 lbs in the placebo-treated patients. After 1 year of treatment, the mean percent weight loss difference between XENICAL-tre...
Three studies were designed to evaluate the effects of XENICAL compared to placebo in reducing weight regain after a previous weight loss achieved following either diet alone (one study, 14302) or prior treatment with XENICAL (two studies, 14119C and 14185). The diet utilized during the 1-year weight regain portion of the studies was a weight-maint...
The treatment effects of XENICAL were examined for 2 years in four of the five 1-year weight management clinical studies previously discussed (see Table 6). At the end of year 1, the patients’ diets were reviewed and changed where necessary. The diet prescribed in the second year was designed to maintain patient’s current weight. XENICAL was shown ...
In the 4-year double-blind, placebo-controlled XENDOS study, the effects of XENICAL in delaying the onset of type 2 diabetes and on body weight were compared to placebo in 3304 obese patients who had either normal or impaired glucose tolerance at baseline. Thirty-four percent of the 1655 patients who were randomized to the placebo group and 52% of ...
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2023年12月4日 · pale skin, shortness of breath, dizziness, weakness, or. tremors. Before using Adrenalin a second time, tell your doctor if your first injection caused serious side effects such as increased breathing difficulty, or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness ...
2022年5月16日 · What Is Norvasc? Norvasc (amlodipine) is a calcium channel blocker (CCB) prescribed for the prevention and treatment of heart pain or chest pain from angina, and for the treatment of high blood pressure. Norvasc is available as a generic drug. What Are Side Effects of Norvasc? Common side effects of Norvasc include: headache,
Drug Summary. What Is Pepcid? Pepcid (famotidine) is an H2-blocker used to treat and prevent recurrence of stomach and duodenal ulcers. Pepcid is also useful in managing heartburn, gastroesophageal reflux disease and Zollinger-Ellison syndrome. Pepcid is available as a generic drug. What Are Side Effects of Pepcid?
2023年7月21日 · What Is Benicar? Benicar (olmesartan medoxomil) is an angiotensin II receptor antagonist used to reduce and control hypertension ( high blood pressure ). Generic Benicar is available outside of the U.S. What Are Side Effects of Benicar? Benicar may cause serious side effects including: lightheadedness. little or no urination.
