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Selenoprotein. In molecular biology a selenoprotein is any protein that includes a selenocysteine (Sec, U, Se-Cys) amino acid residue. Among functionally characterized selenoproteins are five glutathione peroxidases (GPX) and three thioredoxin reductases, (TrxR/TXNRD) which both contain only one Sec. [1] Selenoprotein P is the most common ...
Collocyte. Collocyte is a term variously applied in botany [1] and zoology [2] [3] [4] to cells that produce gluey substances, or that bind or capture prey or assorted objects by securing them with gluey materials and structures, or that simply look smooth and gelatinous. Literally the word means "glue cell", and it has a number of poorly ...
Type IV collagen. Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. Also, collagen IV lacks the regular glycine in every third residue necessary for the ...
- Formation
- Clinical Significance
- See Also
The COL1A1 gene produces the pro-alpha1(I) chain. This chain combines with another pro-alpha1(I) chain and also with a pro-alpha2(I) chain (produced by the COL1A2gene) to make a molecule of type I pro-collagen. These triple-stranded, rope-like pro-collagen molecules must be processed by enzymes outside the cell. Once these molecules are processed, ...
See Collagen, type I, alpha 1#Clinical significance Markers used to measure bone loss are not easily testable. Degradation of type 1 collagen releases metabolites that can be used to monitor resorption.
- Structure
- Function
- Clinical Significance
- External Links
Gene
The COL4A1 gene resides on chromosome 13 at the band 13q34 and contains 54 exons. This gene produces 2 isoforms through alternative splicing.
Protein
COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S domain at its center, and a non-collagenous 1 (NC1) domain at its C-terminal. The triple-helical domain contains interrupted G-X-Y repeats, which is suspected to allow flexibility of the domain. The NC1 domain is composed of two trimeric caps, each containing two alpha 1 fragments and one alpha 2 fragment, that form a sixfold propeller arranged around an axial tunnel....
Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins. Thus, COL4A1 is abundant and found in all types of basement membranes. The NC1 domain of COL4A1 is an important antiangiogenic molecule to control the formation of new capillaries. NC1 binds to the α1β1 integrin and inhibits specif...
Mutations in COL4A1 exons 24 and 25 are associated with HANAC (autosomal dominant hereditary angiopathy with nephropathy, aneurysms, and muscle cramps). It has also been confirmed that mutations in the COL4A1 gene occur in some patients with porencephaly and schizencephaly. In humans, a novel mutation of the COL4A1 gene coding for collagen type IV ...
GeneReviews/NCBI/NIH/UW entry on COL4A1-Related Disorders - Autosomal Dominant Type 1 Porencephaly; Brain Small Vessel Disease with Hemorrhage; Hereditary Angiopathy with Nephropathy, Aneurysms, an...
Collagen, type XXI, alpha 1. Collagen alpha-1 (XXI) chain is a protein that in humans is encoded by the COL21A1 gene. [3] The protein is an extracellular matrix component of blood vessel walls, secreted by smooth-muscle cells. The protein may contribute to the extracellular matrix assembly of the vascular network during blood vessel formation. [4]
Type III Collagen is a homotrimer, or a protein composed of three identical peptide chains (), each called an alpha 1 chain of type III collagen.Formally, the monomers are called collagen type III, alpha-1 chain and in humans are encoded by the COL3A1 gene.Type III collagen is one of the fibrillar collagens whose proteins have a long, inflexible, triple-helical domain.
珍珠膠原蛋白 相關
廣告兩寶媽Lisa教你如何選購膠原蛋白，實測食用半個月，肌膚是否變得更Q彈？了解更多. 各大美妝通路，等琳瑯滿目的膠原蛋白產品，該怎麼挑選呢？兩寶媽Lisa分享實測結果
網友大力推薦蜜露珂娜膠原蛋白，富含活妍三重精華，展現豐.潤.亮.美麗光采，日本製造全台免運. 牛爾老師唯一指定，看不出50歲的祕密就靠蜜露珂娜，每天一包，煥發晶瑩透亮好氣色
特殊多醣與膠原蛋白構成保水網結構，增加玻尿酸的保水能力，搭配微活化薑黃素，讓您有效吸收. 國際專利原料，醫師推薦最有感。美國專利醫師推薦「UC-ll®非變性二型膠原蛋白」，守護關鍵靈活力
