The 1966 Hualien earthquake occurred on March 13 at 00:31 local time of Taiwan. The epicenter was located in the offshore area between Yonaguni Island, Japan and Hualien, Taiwan. The intensity in Yonaguni reached shindo 5. Two people were ...
- Taiwan and Japan
- 1966-03-12 16:31:20
- March 13, 1966
- 8.0 Mₛ
- Pipeline and Clinical Trials
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The word AMGen is a portmanteau of the company's original name, Applied Molecular Genetics, which became the official name of the company in 1983 (three years after incorporation and coincident with its initial public offering). The company's first chief executive officer, from 1980, was co-founder George B. Rathmann, followed by Gordon M. Binder in 1988, followed by Kevin W. Sharer in 2000.Robert A. Bradway became Amgen’s president and chief executive officer in May 2012 following Sharer's retirement. The company has made at least five major corporate acquisitions.1980. William Bowes from Cetus Corporation recruits Winston Salser from UCLA to start Amgen with a scientific advisory board consisting of Norman Davidson, Leroy Hood, Arnold Berk, John Carbon, Rob...1989. Amgen received approval for the first recombinant human erythropoetin product, Epogen, for the treatment of anemia associated with chronic kidney failure. Epogen (also marketed by Johnson and...1991. In February 1991, Amgen received FDA approval for Neupogen for the prevention of infections in patients whose immune systems are suppressed due to cancer chemotherapy.A 2002 meta-analysis fou...1998. In November 1998, Immunex, a future acquisition of Amgen, received approval for Enbrel (etanercept), the first rheumatoid arthritis drug targeting tumor necrosis factor alpha (TNF-alpha). A 2...
Amgen's approved drugsor therapeutic biologicals include: 1. AIMOVIG (erenumab-aooe) for migraine headaches 2. Aranesp (darbepoetin alfa) for anemia 3. BLINCYTO (blinatumomab for the treatment of acute lymphoblastic leukemia) 4. Corlanor (ivabradine) 5. Enbrel (etanercept) for various forms of arthritis 6. EPOGEN (erythropoietin) for anemia 7. EVENITY (romosozumab-aqqg) for osteoporosis 8. IMLYGIC (talimogene laherparepvec) for local treatment of unresectable cutaneous, subcutaneous, and nodal lesions in melanoma recurrent after initial surgery 9. Kyprolis (carfilzomib) 10. Neulasta (pegfilgrastim) for neutropenia 11. NEUPOGEN (granulocyte colony-stimulating factor) for neutropenia 12. Nplate (romiplostim) for chronic immune thrombocytopenic purpura 13. Parsabiv (etelcalcetide) 14. Prolia (denosumab) for postmenopausal osteoporosis 15. Repatha (evolocumab) 16. Sensipar/Mimpara (cinacalcet for primary and secondary hyperparathyroidism, a mineral metabolism complication common in pati...
In December 2013, Amgen had 11 drugs in Phase III clinical trials. In November 2014 the company announced it was halting all trials of rilotumumab in advanced gastric cancer patients after one of the trials found more deaths in those who took the compound with chemotherapy, than those without. Later in the same week, the company in conjunction with AstraZeneca reported positive results for brodalumab in a Phase III trial comparing the compound with ustekinumab and a placebo in treating psoriasis. In March 2015, the company announced it would license its Phase II candidate drug AMG 714 to developer Celimmune who plan to develop the anti-IL-15 monoclonal antibody for treatment against diet nonresponsive celiac diseaseand refractory celiac disease. In June 2015, Amgen presented Phase II clinical trial data for their anti-CGRP antibody AMG 334 for migraine, approved for sale as AIMOVIG in 2019. In 2019, the US Food and Drug Administration has granted fast track designation to AMG 510 fo...Kirin-Amgen v Hoechst Marion Roussel, a UK patent case decided by the House of Lords
- Popular Culture
The original story
One story says that Xuanwu was originally a prince of Jing Le State in northern Hebei during the time of the Yellow Emperor. As he grew up, he felt the sorrow and pain of the life of ordinary people and wanted to retire to a remote mountain for cultivation of the Tao.
Qing Dynasty version
Another says that Xuanwu was originally a butcher who had killed many animals unremorsefully. As days passed, he felt remorse for his sins and repented immediately by giving up butchery and retiring to a remote mountain for cultivation of the Tao. One day he was assisting a woman in labor, while cleaning the woman's blood stained clothes along a river, the words "Dark (or Mysterious) Heavenly Highest Deity" (玄天上帝 Xuántiān Shàngdì) appeared before him. The woman in labor turned out to be a man...
Generals Wan Gong and Wan Ma
Xuanwu is sometimes portrayed with two generals standing besides him, General Wan Gong (萬公) and General Wan Ma (萬媽). The two generals are deities that handle many local issues from children's birth, medication, family matters as well as fengshuiconsultation.
Xuanwu is portrayed as a warrior in dark-coloured imperial robes, his left hand holding the "three mountain seal", somewhat similar to Guan Yu's hand seal, while his right hand is holding a sword, which is said to have belonged to Lü Dongbin, one of the Eight Immortals. Another legend says that he borrowed the sword from Lü Dongbin to subdue a strong demon, and after being successful, he refused to bring it back after witnessing the sword's power. The sword itself would magically return to it...
Worship in Indonesia
In Indonesia, almost every Taoist temple provides an altar for Xuantian Shangdi. The story states that the first temple that worshiped him was a temple at Welahan Town, Jepara, Central Java. And the temples that were built in honor of him are the temples at Gerajen and Bugangan, Semarang City, Central Java. His festival is celebrated annually every the 25th day, 2nd month, of Chinese calendar. The worshipers of Chen Fu Zhen Ren, especially at Tik Liong Tian Temple, Rogojampi, Banyuwangi Regen...
Worship in Thailand
Xuanwu is known among the Thai people as Chao Pho Suea (Tiger God) or Tua Lao Yah (大老爷 "Big Deity") according by Teochew dialect. There are many shrines that worship him in the country and the most famous shrine is Bangkok's San Chao Pho Suea near Giant Swing and Sam Phraeng neighbourhood. This shrine has been highly worshipped with both Thais and Chinese, especially in Chinese New Year's Day.In the classic novel Journey to the West, Xuanwu was a king of the north who had two generals serving under him, a "Tortoise General" and a "Snake General". This king had a temple at Wudang Mountai...In recent times, Xuanwu is a central character in the popular urban fantasy series by Kylie Chan: The Dark Heavens Trilogy, the Journey to Wudang Trilogy, and the Celestial BattleTrilogy.Xuanwu lives in Kansas City and is served by monks and shadow-shifting ninjas in Shayne Silver's book Black Sheepwhich is part of the Feathers and Fire series.