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What is glimepiride used for?
Is Amaryl a glimepiride?
Is glimepiride a sulfonylurea?
Does glimepiride affect blood glucose?
Dosage. Side Effects. Drug Interactions. Warnings and Precautions. What Is Glimepiride and How Does It Work? Glimepiride is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. It may also be used with other diabetes medications.
- Hypoglycemia
- Hypersensitivity Reactions
- Hemolytic Anemia
- Increased Risk of Cardiovascular Mortality with Sulfonylureas
- Macrovascular Outcomes
- Carcinogenesis, Mutagenesis, and Impairment of Fertility
- Pregnancy
- Nursing Mothers
- Pediatric Use
- Geriatric Use
All sulfonylureas, including AMARYL, can cause severehypoglycemia [see ADVERSE REACTIONS]. The patient's ability toconcentrate and react may be impaired as a result of hypoglycemia. These impairmentsmay present a risk in situations where these abilities are especiallyimportant, such as driving or operating other machinery. Severe hypoglycemiacan le...
There have been postmarketing reports of hypersensitivityreactions in patients treated with AMARYL, including serious reactions such asanaphylaxis, angioedema, and Stevens-Johnson Syndrome. If a hypersensitivityreaction is suspected, promptly discontinue AMARYL, assess for other potential causesfor the reaction, and institute alternative treatment ...
Sulfonylureas can cause hemolytic anemia in patients withglucose 6-phosphate dehydrogenase (G6PD) deficiency. Because AMARYL is asulfonylurea, use caution in patients with G6PD deficiency and consider the useof a non-sulfonylurea alternative. There are also postmarketing reports ofhemolytic anemia in patients receiving AMARYL who did not have known...
The administration of oral hypoglycemic drugs has beenreported to be associated with increased cardiovascular mortality as comparedto treatment with diet alone or diet plus insulin. This warning is based on thestudy conducted by the University Group Diabetes Program (UGDP), a long-term, prospectiveclinical trial designed to evaluate the effectivene...
There have been no clinical studies establishingconclusive evidence of macrovascular risk reduction with AMARYL or any otheranti-diabetic drug.
Studies in rats at doses of up to 5000 parts per million(ppm) in complete feed (approximately 340 times the maximum recommended humandose, based on surface area) for 30 months showed no evidence of carcinogenesis.In mice, administration of glimepiride for 24 months resulted in an increase inbenign pancreatic adenoma formation that was dose-related ...
There are no adequate and well-controlled studies ofAMARYL in pregnant women. In animal studies there was no increase in congenitalanomalies, but an increase in fetal deaths occurred in rats and rabbits atglimepiride doses 50 times (rats) and 0.1 times (rabbits) the maximumrecommended human dose (based on body surface area). This fetotoxicity,obser...
It is not known whether AMARYL is excreted in human milk.During pre- and post-natal studies in rats, significant concentrations ofglimepiride were present in breast milk and the serum of the pups. Offspring ofrats exposed to high levels of glimepiride during pregnancy and lactationdeveloped skeletal deformities consisting of shortening, thickening,...
The pharmacokinetics, efficacy and safety of AMARYL havebeen evaluated in pediatric patients with type 2 diabetes as described below.AMARYL is not recommended in pediatric patients because of its adverse effectson body weight and hypoglycemia. The pharmacokinetics of a 1 mg single dose of AMARYL wasevaluated in 30 patients with type 2 diabetes (mal...
In clinical trials of AMARYL, 1053 of 3491 patients (30%)were > 65 years of age. No overall differences in safety or effectivenesswere observed between these patients and younger patients, but greatersensitivity of some older individuals cannot be ruled out. There were no significant differences in glimepiridepharmacokinetics between patients with ...
2023年8月15日 · This is not a complete list of side effects and other serious side effects or health problems that may occur because of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.
2022年11月9日 · Avandaryl (Rosiglitazone Maleate and Glimepiride) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.
2023年7月13日 · Drug Summary. What Is Tradjenta? Tradjenta (linagliptin) tablets are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. What Are Side Effects of Tradjenta? Tradjenta may cause serious side effects including: severe pain in your upper stomach spreading to your back, nausea, vomiting,
Medications and prescription drug information for consumers and medical health professionals. Online database of the most popular drugs and their side effects, interactions, and use. Cuts, Scrapes, Wounds, Bruises, Burns Stratagraft (Allogeneic Cultured
2023年8月15日 · What Is Duetact? Duetact (pioglitazone hydrochloride and glimepiride) Tablets are a combination of two oral antihyperglycemic agents used to control blood sugar levels for people with type 2 diabetes who do not use daily insulin injections. What Are Side Effects of Duetact? Duetact may cause serious side effects including: hives,
