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George Hripcsak, MD, MS; Marc A. Suchard, MD, PhD; Steven Shea, MD; RuiJun Chen, MD; Seng Chan You, MD; Nicole Pratt, PhD; David Madigan, PhD; Harlan M. Krumholz, MD, SM; Patrick B. Ryan, PhD; Martijn J. Schuemie, PhD To the Editor Hripcsak et al 1 compared cardiovascular and safety outcomes of chlorthalidone and hydrochlorothiazide in the treatment of patients with hypertension ...
- Andrew E. Moran, Paul K. Whelton, Thomas R. Frieden
- 2020
2021年9月15日 · Key Points Question What are the safety and clinical outcomes associated with chlorthalidone or hydrochlorothiazide use among older adults with varying levels of kidney function? Findings In this cohort study of 12 722 older adults, chlorthalidone use was associated with a higher risk for eGFR decline of 30% or more, cardiovascular events, and hypokalemia compared with hydrochlorothiazide use.
- Cedric Edwards, Gregory L Hundemer, William Petrcich, Mark Canney, Greg Knoll, Kevin Burns, Ann Buge...
- 2021
Importance Chlorthalidone is currently recommended as the preferred thiazide diuretic to treat hypertension, but no trials have directly compared risks and benefits. Objective To compare the effectiveness and safety of chlorthalidone and hydrochlorothiazide as first-line therapies for hypertension in real-world practice. ...
This Review of hypertension treatment discusses first-line strategies to control blood pressure, including lifestyle modification, and therapies such as thiazide diuretics, ACE inhibitors, ARB blockers, and calcium channel blockers.
To the Editor In their retrospective observational cohort study, Hripcsak et al1 reported similar efficacy of chlorthalidone (CTD) and hydrochlorothiazide (HCTZ) in the treatment of patients with hypertension but distinct differences in safety, favoring HCTZ. The authors correctly observed that...
This randomized clinical trial compares 4 different classes of blood pressure–lowering drugs—lisinopril, candesartan, hydrochlorothiazide, and amlodipine—for their potential to be targeted to specific individuals to maximize blood pressure effects.
Thiazides and thiazidelike diuretics have remained a cornerstone in the management of hypertension for more than half a century since their introduction in 1958. 1,2 Very few agents used for the treatment of any disease can boast such staying power, which is a testament both to the efficacy and safety of these compounds and to the relevance of salt and volume control in the management of ...
