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  1. 16 小時前 · lovastatin pitavastatin pravastatin rosuvastatin simvastatin These may differ by how much the body absorbs, which enzymes process the statin, how the statins interact with cells, and how the body ...

  2. 4 天前 · Overall, statins reduce TG levels in the range of 10% to 20% ( Table ), although it has been acknowledged that the higher the baseline TG level, the greater the TG-lowering effect. For example, baseline TG levels exceeding 250 mg/dL have been associated with reductions in the range of 22% to 45%, whereas more modest reductions have been ...

  3. 3 天前 · There are differences among the statins in terms of their propensity to cause myopathy. The statins that carry a higher than average overall risk are among the more potent: lovastatin (Mevacor, Merck; Altocor, Andrx; and generic) and simvastatin (Zocor, Merck).

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  5. 5 天前 · Directly compare the efficacy of one drug to the other. Underpowered for a head-to-head comparison of mg-equivalent doses of the 2 most potent statins, ARIES does show benefits for LDL-C reduction in an unfortunately ignored population, African Americans.

  6. 1 天前 · It has the advantage of a long half-life compared to other statins (e.g., lovastatin, fluvastatin, and simvastatin), with the half-life of atorvastatin reported to be approximately 7 h. However, the half-life of its HMG-CoA reductase inhibitory activity is approximately 13–16 h, owing to the action of its active metabolite [ 32 , 33 , 34 ].

  7. 1 天前 · Background: the purpose of this systematic review was to assess the clinical and radiographic effect of subgingival-administered statins as an adjunct periodontal treatment in patients with periodontitis. Methods: Electronic literature searches in Medline/PubMed and the Cochrane Library were conducted to identify all relevant articles. Eligibility was based on inclusion criteria which included ...

  8. 5 天前 · Some studies, such as one showing an association between lovastatin use and reduced melanoma incidence (OR, 0.52; 95% CI: 0.27–0.99, p = 0.04), suggest potential benefits [7]. In vitro research has demonstrated that statins can inhibit melanoma metastasis and augment treatment in BRAF inhibitor-resistant melanomas when used with other drugs [ 3 ].

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