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Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus.
- 1 to 3 weeks following exposure
- Brincidofovir
- variola major virus, variola minor virus (spread between people)
- Supportive care
The history of smallpox extends into pre-history. [1] Genetic evidence suggests that the smallpox virus emerged 3,000 to 4,000 years ago. [2] Prior to that, similar ancestral viruses circulated, but possibly only in other mammals, and possibly with different symptoms.
The smallpox vaccine is the first vaccine to have been developed against a contagious disease. In 1796, British physician Edward Jenner demonstrated that an infection with the relatively mild cowpox virus conferred immunity against the deadly smallpox virus.
- AU: D
- Live virus
- ACAM2000, Imvanex, Jynneos, others
- Smallpox
This article discusses smallpox as it existed in Mozart's time, the decision taken in 1764 by Mozart's father Leopold not to inoculate his children against the disease, the course of Mozart's illness, and the aftermath.
George Washington by Charles Willson Peale, 1776. The New World of the Western Hemisphere was devastated by the 1775–1782 North American smallpox epidemic. Estimates based on remnant settlements say at least 130,000 people were estimated to have died in the epidemic that started in 1775. [1]
Edward Jenner FRS FRCPE [1] (17 May 1749 – 26 January 1823) was an English physician and scientist who pioneered the concept of vaccines and created the smallpox vaccine, the world's first vaccine. [2] [3] The terms vaccine and vaccination are derived from Variolae vaccinae ('pustules of the cow'), the term devised by Jenner to denote cowpox.
1978 smallpox outbreak in the United Kingdom. The East Wing of the University of Birmingham Medical School, which was the source of the outbreak. The 1978 smallpox outbreak in the United Kingdom resulted in the death of Janet Parker, a British medical photographer, who became the last recorded person to die from smallpox.
