搜尋結果
An mRNA vaccine is a type of vaccine that uses a copy of a molecule called messenger RNA (mRNA) to produce an immune response. [1] .
The Pfizer–BioNTech COVID-19 vaccine, sold under the brand name Comirnaty, is an mRNA-based COVID-19 vaccine developed by the German biotechnology company BioNTech. For its development, BioNTech collaborated with the American company Pfizer
- Comirnaty
- mRNA
The vaccine's efficacy spans various demographics, including age, sex, and those with high-risk medical conditions. It is an mRNA vaccine composed of nucleoside-modified mRNA (modRNA) encoding a spike protein of SARS-CoV-2, which is encapsulated in .
- AU: B1
- SARS-CoV-2
- Spikevax
- mRNA
According to studies, the combination of two different COVID‑19 vaccines, also called cross-vaccination or the mix-and-match method, provides protection equivalent to that of mRNA vaccines, including protection against the Delta variant.
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- Intramuscular
- mRNA, viral, inactivated, protein
- SARS-CoV-2
- Background
- Overview
- Significance of Untranslated Regions
- Delivery
- Applications
- Further Reading
mRNA is produced by synthesising a ribonucleic acid (RNA) strand from nucleotide building blocks according to a deoxyribonucleic acid (DNA) template, a process that is called transcription. When the building blocks provided to the RNA polymerase include non-standard nucleosides such as pseudouridine — instead of the standard adenosine, cytidine, gu...
To induce cells to make proteins that they do not normally produce, it is possible to introduce heterologous mRNA into the cytoplasm of the cell, bypassing the need for transcription. In other words, a blueprint for foreign proteins is "smuggled" into the cells. To achieve this goal, however, one must bypass cellular systems that prevent the penetr...
A normal mRNA starts and ends with sections that do not code for amino acids of the actual protein. These sequences at the 5′ and 3′ ends of an mRNA strand are called untranslated regions(UTRs). The two UTRs at their strand ends are essential for the stability of an mRNA and also of a modRNA as well as for the efficiency of translation, i.e. for th...
Various difficulties are involved in the introduction of modRNA into certain target cells. First, the modRNA must be protected from ribonucleases. This can be accomplished, for example, by wrapping it in liposomes. Such "packaging" can also help to ensure that the modRNA is absorbed into the target cells. This is useful, for example, when used in v...
An important field of application are mRNA vaccines. Replacing uridine with pseudouridine to evade the innate immune system was pioneered by Karikó and Weissman in 2005.They won the 2023 Nobel Prize in Physiology or Medicine as a result of their work. Another milestone was achieved by demonstrating the life-saving efficacy of nucleoside modified mR...
Badieyan ZS, Evans T (August 2019). "Concise Review: Application of Chemically Modified mRNA in Cell Fate Conversion and Tissue Engineering". Stem Cells Translational Medicine. 8 (8): 833–843. doi:...Espeseth AS, Cejas PJ, Citron MP, Wang D, DiStefano DJ, Callahan C, et al. (2020). "Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are imm...Moderna, Inc. ( / məˈdɜːrnə / mə-DUR-nə) [4] is a pharmaceutical and biotechnology company based in Cambridge, Massachusetts, that focuses on RNA therapeutics, primarily mRNA vaccines. These vaccines use a copy of a molecule called messenger RNA (mRNA) to carry instructions for proteins to produce an immune response.
An mRNA vaccine (or RNA vaccine) is a novel type of vaccine which is composed of the nucleic acid RNA, packaged within a vector such as lipid nanoparticles. Among the COVID-19 vaccines are a number of RNA vaccines to combat the COVID-19 pandemic and some have been approved or have received emergency use authorization in some countries.
